Dr. GPCR Podcast

About Dr. Claudia Stäubert

"I received my degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors (GPCRs) due to a stay as a scholarship student in the lab of Thue Schwartz (Copenhagen, Denmark). This fascination accompanied me and repeatedly challenged me ever since. During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins”, I focused on the evolutionary aspects of GPCRs. As a postdoc in the lab of Anders Nordström (Umeå, Sweden), I broadened my methodical and scientific horizon and focused on cellular metabolism and drug resistance phenomenon applying metabolomics analyses. Since 2014, I have led a research group at the Rudolf Schönheimer Institute of Biochemistry in Leipzig (Germany). We focus on several aspects of metabolite-sensing GPCRs including signal transduction, intracellular trafficking, and evolution. Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. "

Dr. Claudia Stäubert on the web

• Stäubert Lab, Rudolf Schönheimer Institute of Biochemistry Leipzig

• LinkedIn

• ResearchGate

• ORCID

• ResearcherID

• Scopus Author ID

• Google Scholar

• PubMed

• Twitter

• Dr. GPCR

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Quick recap

Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and their effects on the system. They also discussed the challenges of studying metabolites and their receptors, the relationship between metabolites, gut health, and disease progression, and Claudia's career journey in academia. They also explored the possibility of developing an ecosystem for the GPCR University.

Summary

Interview and Social Media Planning

Yamina, from Dr. GPCR, discussed with Claudia, a guest from the Schiller Institute at Campstream, about Claudia's work and future plans. Yamina mentioned that they would use their discussion as a basis for crafting social media posts. Claudia, who has an interest in metabolites and their effects on the system, agreed. Yamina also pointed out that Claudia was their first guest of the year, indicating the start of a new series of interviews.

Affordable Childcare and GPCR Research Discussion

Yamina and Claudia discussed the importance of affordable childcare and the experiences of PhD students in the US and Europe. Claudia shared her experiences working in Sweden and Germany, and how she secured funding for her research on the effects of metabolites on GPCRs. Yamina expressed interest in attending a meeting about GPCRs and metabolism in the UK, but was unsure if she could make it due to travel constraints.

Metabolite Activation of GPCRs: A Fascinating Discovery

Claudia and Yamina discussed the role of metabolites in activating GPCRs, a process that they found fascinating. Yamina expressed interest in learning more about this topic as she realized her lack of knowledge on metabolite recognition or binding to GPCRs. Claudia suggested possible next steps, including researching review articles or articles to gain a higher understanding of what is known about this process.

Challenges in Studying Metabolites and Receptors

Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They acknowledged the difficulty of distinguishing between different compounds and the effect of media on the cellular system. They also explored the potential for better tools to understand and discover new metabolites or receptors. Yamina suggested the possibility of using native cells with optimized media, but Claudia highlighted the complexity of the system. They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into detail.

Metabolites, Gut Health, and Disease Progression

Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Yamina proposed that the metabolites in the gut of a non-healthy person might be different from those of a healthy person, which could affect receptor activity. Claudia agreed, suggesting that the complexity of the gut microbiome is akin to a "complicated city vicus". Yamina shared an example she heard in a podcast about fecal transplants and the relationship between the gut, brain, and metabolism. Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect the metabolites and not necessarily lack inherited genes.

Academia, Career Journeys, and Advice

Yamina and Claudia discussed Claudia's career journey in academia. Claudia shared her experiences and her love for her work, emphasizing the importance of research and learning in academia. Yamina highlighted the challenges of career choices, especially when family situations are involved. Claudia also mentioned the significant experiences that shaped her career trajectory, such as her time in an assurance lab and her trip to Sweden. Towards the end, Claudia offered advice to junior scientists, suggesting that they explore different fields and meet a variety of people to find their interests. She also mentioned her team's job openings and where people could find more information.

Developing a Research Ecosystem at GPCR University

Yamina and Claudia discussed developing an ecosystem for the GPCR University, with the goal of providing a central hub for researchers in the field. Yamina emphasized its vision for the platform to be a place where researchers can find content, ask questions, and collaborate, thereby avoiding the repetition of unsuccessful studies. They also touched on the potential for funding from external sources. Claudia briefly mentioned a recommendation from the Committee on Petitions.