Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. 

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➡https://www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/design-of-allosteric-modulators-that-change-gpcr-g-protein-subtype-selectivity 

#gpcr #drgpcr

Ready to stand out in the GPCR world? Take advantage of a platform where you can network within your field! 🌍 Showcase your expertise by keeping your profile up-to-date on Dr. GPCR.

✳️Start today at https://www.ecosystem.drgpcr.com/account/my-account

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Exploring the combination of molecular simulation, pharmacological assays, and NMR to reveal the molecular mechanism of biased activation at the vasopressin V2 receptor.

Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership!

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-affinity-elr%2B-chemokine-ligands-show-g-protein-bias-over-%CE%B2-arrestin-recruitment-and-receptor-internalization-in-cxcr1-signalling 

#gpcr #drgpcr

Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling.

➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a-bitter-anti-inflammatory-drug-binds-at-two-distinct-sites-of-a-human-bitter-taste-gpcr?utm_campaign=5d751e7a-3ecb-4719-8ba3-974d17e9f596&utm_source=so&utm_medium=mail&cid=79a6b35e-7ba6-44a0-863b-0842f5a5cfd3

 #gpcr #drgpcr #bittertaste

A well-updated profile opens doors to collaborations and exciting GPCR projects 🚀  Don’t miss out—update yours now! 

✳️ Go to https://www.ecosystem.drgpcr.com/account/my-account and meet all the fantastic scientists that are part of our community 😉

#gpcr #drgpcr

Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem!

➡️ buff.ly/4fgX4ZH

#gpcr #drgpcr

Do you know that dilated cardiomyopathy, a disease that makes it harder for the heart to pump blood to the rest of the body, results from the deficiency of Latrophilin-2? Check out this paper to understand the function of Latrophilin-2 and how it leads to dilated cardiomyopathy.

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➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/latrophilin-2-deletion-in-cardiomyocyte-disrupts-cell-junction%2C-leading-to-d-cmp

Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6-and-cxcr1 

⚠️ Registration Deadline today! This is your last chance to register for Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection with Dr. Terry Kenakin. Learn more about new ligands and new GPCR behaviors that produce unique drug profiles.

✳️ Last chance!!! https://www.ecosystem.drgpcr.com/advanced-methods-for-the-optimization-of-candidate-selection 

#gpcr #drgpcr

GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression? New research sheds light on these pathways! ✨ Want to learn more? 

Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership!

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells

#GPCR #DrGPCR

In case you haven’t heard, Dr. Terry Kenakin will soon start the course Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection 📖 The five-lecture series describes essential additional elements to GPCR discovery programs that extend the discovery process and increase therapeutic opportunity.

✳️ Register today! https://www.ecosystem.drgpcr.com/advanced-methods-for-the-optimization-of-candidate-selection 

#gpcr #drgpcr

New biosensor technologies are shedding light on GPCR dynamics directly in cells, offering exciting possibilities for multiplexing and miniaturization! Curious about how these advances could impact drug discovery? Check out the latest review on GPCR biosensors.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/reviews/gpcr-biosensors-to-study-conformational-dynamics-and-signaling-in-drug-discovery

#GPCR #DrGPCR #biosensor