Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free!

➡️https://buff.ly/e6gAlBv

#gpcr#drgpcr

From aspiring doctor to GPCR scientist! 🔬In this episode, Ian Chronis shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling. Can you guess what’s his favorite GPCR?

✅ Hear his response: Ep 164 with Dr. Ian Chronis 

#SciencePodcast #GPCR #PhDLife #DrGPCR

What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments!

✅ Tune in: https://buff.ly/FTB69y9 

#GPCR #DrGPCR #SciencePodcast

Behind every great discovery is a great question 🚀

Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode.

If you’re passionate about GPCRs and drug discovery, this episode is a must-listen!

✳️Listen at Ep 163 with Dr. Dmitry Veprintsev  

#DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience

In Ep.163 of the Dr. GPCR Podcast, Dr. Dmitry Veprintsev discusses the importance of asking the right GPCR question. It’s not just about learning the techniques; it’s about curiosity! 👀

Do you remember any question that changed your perspective completely? 💡 

✳️Visit https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-  

#DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #GPCRScience

A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders.

Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function

#GPCR #drGPCR #FFA4 #metabolism #adipocytes

What are your thoughts on β2AR? Listen to Ep.163 of the @DrGPCR Podcast, where @DVeprintsev shares his thoughts and experiences about working with GPCRs, tips on framing your research correctly, and other insightful topics. Don’t miss out!

✳️https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry- 

#GPCRs #SciencePodcast #DrugDiscovery #Biotech #DrGPCR

New Episode Alert! 🎙️

Ep. 163 of the Dr. GPCR Podcast is here! 🚀 This time, we sit down with Dr. Dmitry Veprintsev to discuss the importance of asking the right GPCR questions.

Whether you're a researcher, student, or GPCR enthusiast, this episode is packed with insights that will challenge how you think about your experiments.

✳️Tune in at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-  

#DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #Biotech #GPCRs

How does a superagonist activate M2 muscarinic receptors? New simulations reveal the conformational changes from inactive to active states to highlighting how ligand dynamics drive GPCR activation!  

Catch the full story in the Ecosystem!

https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics

#GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics

🎧 "You will always feel like you know nothing— and that’s completely fine."

In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren shares:🔬 How GPCR spatial organization shapes signaling and drug responses🌍 His interdisciplinary journey from physics to pharmacology💡 Why embracing the unknown is key to scientific breakthroughs

A must-listen for biophysicists, pharmacologists, and drug hunters pushing the boundaries of discovery!

🎙️ Tune in now:Ep 162 with Dr. Gabriele Kockelkoren 

#DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast

A newly engineered biosensor reveals DNAJC13 as a key player in GPCR trafficking, shedding light on its role in DOR downregulation and endosomal regulation.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation 

#gpcr #drgpcr

How does nanoscale GPCR organization shape signaling? 🤔 We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics.

And if you wonder what his favorite GPCR could be, here’s the answer 😉

✅Listen now Ep 162 with Dr. Gabriele Kockelkoren  

#gpcr #drgpcr

🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response.

In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into:

🔬 How GPCR trafficking shapes signaling outcomes

🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs!

🎙️ Listen now https://buff.ly/fYZ1tSq 

#DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast

✅ Tune in today!

A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways 

#gpcr#drgpcr

Do you remember the first time you were left alone in the lab with an experiment? 🤔 Did your experience compare to Dr. Brian Hudson’s? 😄

Tune into this week’s Dr. GPCR Podcast for great stories, GPCR insights, and a fascinating journey that led Dr. Hudson to years of groundbreaking research at the University of Glasgow. Don’t miss out!

✅Listen now https://buff.ly/aEQGUFl

#gpcr #drgpcr

🎯 Crack the code of GPCR ligand development!

In case you haven’t heard, Dr. Terry Kenakin is hosting a 4-week course on GPCR drug development—and registration closes in 3 days! ⚠️

What you’ll learn:✅ Drug absorption, metabolism & clearance✅ PK-PD modeling & therapeutic profiles✅ Early safety assessments & toxicity risks

📌 Limited spots—sign up before March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem 

#GPCR #DrGPCR #Pharma #Biotech #Research

🚨 Exciting Opportunity for Professionals in Drug Development! 🚨

Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs."

🗓 Dates: March 20 - April 10, 2025

⏰ Time: Thursdays, 10:00 AM - 11:30 AM (EST)

This advanced course is essential for anyone working in drug development and focuses on:

The essentials of new drug development

Key pharmacokinetic elements (absorption, distribution, clearance)

Hepatic metabolism and the Cytochrome P450 system

Drug safety and toxicology (including drug-drug interactions)

And much more!

Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to bring therapeutic molecules to life.

🚨 Only 25 spots available — register now!

💡 This is a great opportunity for both academia and industry professionals. Sessions will be live, and you’ll also have 1:1 discussion time with the instructor. Full PDFs of the slides will be available!

🔗 https://buff.ly/lVEcRUc

#GPCR #DrugDevelopment #Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry

🔬 Enhance Your GPCR Expertise with Dr.GPCR University!

Looking to sharpen your skills in GPCR pharmacology, drug discovery, data analysis, or project management? Dr.GPCR University offers industry-focused courses designed to help you stay ahead in the field.

✅ Comprehensive course library covering cutting-edge GPCR science✅ Practical insights for real-world drug discovery challenges✅ Flexible, on-demand learning to fit your schedule

🚀 Elevate your expertise today: Start learning now

#GPCR #Pharmacology #DrugDiscovery #Biotech #DrGPCR

Did you know that A2B adenosine receptor-triggered calcium mobilization varies by cell type? A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling, revealing a more complex regulation than previously thought.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c

#gpcr #drgpcr #metabolism #obesity

⏳ In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March 18th!

If you’re working on GPCR drug discovery, you know that finding a promising candidate is just the start. A drug must also:✅ Be absorbed into the body✅ Reach the right target✅ Stay long enough to be effective✅ Cause no harm

📢 Spots are limited—register by March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem  

#GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery

💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology.

🔹 What you’ll learn:✅ Drug Development Basics – Absorption, metabolism, PK principles✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics✅ PK-PD Modeling – Predicting drug behavior, non-linear PK✅ Early Drug Safety – Toxicity risks & drug interactions

📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem  

#GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery

📢 All 2025 Dr.GPCR Courses Are Open for Registration!

Which one will you choose? 🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course for you.

💡 Bonus: Premium Members enjoy 25% off on all courses!

🔗 Explore & register today: https://www.ecosystem.drgpcr.com/gpcr-courses 

#GPCR #DrGPCR #Biotech #DrugDiscovery #Pharmacology

🚀 New Workshop: Practical Quantification of Allosteric Modulation

Join Dr. Terry Kenakin on May 1st, 2025, for an advanced live workshop on allosteric modulators in GPCR drug discovery.

Learn how to:✔️ Identify, measure, and quantify allosteric properties✔️ Apply functional allosteric models to determine mechanisms of action✔️ Confirm allostery through kinetic analysis

📅 Date: May 1st, 2025⏳ Registration deadline: April 18th📍 Live on Google Meet

🔗 Register now: https://www.ecosystem.drgpcr.com/event-details-registration/practical-quantification-of-allosteric-modulation 

#GPCR #Allostery #DrugDiscovery #Pharmacology

Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity?  recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders!

Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free!

➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes 

#gpcr #drgpcr #metabolism #obesity

🚀 Ready to dive into the world of GPCR drug development? Join Dr. Terry Kenakin for the 4-week course “Development of GPCR Ligands as Therapeutic Drugs”! Get exclusive access to expert lectures, recordings, reading materials, and even a private call with Dr. Kenakin himself! Don’t miss this chance to level up your knowledge. 🔹 Spots are limited—save yours now! 👉 https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs  #gpcr #drgpcr #pharmacolgy #drugdiscovery #research