GPCR News 

The journey of a PhD is a unique blend of intellectual discovery, resilience, and personal growth. My experience has been no different,...

Deep mutational scanning (DMS) is a powerful method for studying the functional consequences of various genetic variants within a...

G protein-coupled receptors (GPCRs) are membrane-bound proteins that sense external stimuli and relay signals inside the cell, resulting...

G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological processes and serving...

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case study is essential to deepen...

Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR) structures,...

Biased agonism is a phenomenon where different ligands acting on the same receptor trigger distinct signaling pathways, leading to varied...

Significant advancements in the cellular biology of G protein-coupled receptors (GPCRs) about a novel biosensor shed light on the...

“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to dramatic, either locally or...

The advent of AlphaFold2 (AF2) has brought AI applications in drug development to unprecedented heights. Its groundbreaking ability to...

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting external stimuli into...

One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors (GPCRs) and receptor...

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation, as well as to play vital...

“The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.” Sir William Osler Scientists have...

Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the external environment. These...

G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular signals, including hormones,...

April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure in 1953 and the completion of...

GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations that recruit and ultimately...

When it comes to signal transduction, cellular context matters. The cellular context is crucial for understanding the diverse signaling...

The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious diseases (Proudfoot 2002), and in...