Blog: Blog2

GPCR News

Nov 263 min read

Reflections on My PhD Journey: Lessons Learned

The journey of a PhD is a unique blend of intellectual discovery, resilience, and personal growth. My experience has been no different,...

Harnessing Deep Mutational Scanning for Enhanced Drug Discovery

Cam Sinh Lu

Nov 124 min read

GPCR Articles

Harnessing Deep Mutational Scanning for Enhanced Drug Discovery

Deep mutational scanning (DMS) is a powerful method for studying the functional consequences of various genetic variants within a...

John Teye Azietaku

Oct 293 min read

GPCR Articles

Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling

G protein-coupled receptors (GPCRs) are membrane-bound proteins that sense external stimuli and relay signals inside the cell, resulting...

Monserrat Avila-Zozaya

Oct 222 min read

GPCR Articles

Profiling Immune Cell and Platelet Transcriptomes

G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological processes and serving...

Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR

Cam Sinh Lu

Oct 83 min read

GPCR Articles

Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case study is essential to deepen...

Ya-Tzu Li

Oct 12 min read

GPCR Articles

AlphaFold’s Breakthrough in GPCR Research: Revolutionizing Discovery, Yet Awaiting Experimental Proof

Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR) structures,...

John Teye Azietaku

Sep 234 min read

GPCR Articles

Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes

Biased agonism is a phenomenon where different ligands acting on the same receptor trigger distinct signaling pathways, leading to varied...

Monserrat Avila-Zozaya

Sep 102 min read

GPCR Articles

APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking

Significant advancements in the cellular biology of G protein-coupled receptors (GPCRs) about a novel biosensor shed light on the...

Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery

Cam Sinh Lu

Sep 34 min read

GPCR Articles

Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery

“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to dramatic, either locally or...

Do You Believe AI Could Accelerate Drug Discovery?

Ya-Tzu Li

Jun 253 min read

GPCR Articles

Do You Believe AI Could Accelerate Drug Discovery?

The advent of AlphaFold2 (AF2) has brought AI applications in drug development to unprecedented heights. Its groundbreaking ability to...

John Teye Azietaku

Jun 183 min read

GPCR Articles

Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting external stimuli into...

Monserrat Avila-Zozaya

Jun 113 min read

GPCR Articles

Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered

One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors (GPCRs) and receptor...

Inês Pinheiro

Jun 42 min read

GPCR Articles

Canonical chemokine receptors as scavenging “decoys”

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation, as well as to play vital...

Cam Sinh Lu

May 283 min read

GPCR Articles

Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery

“The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.” Sir William Osler Scientists have...

Dynamic GPCR activation revealed through time-resolved Cryo-EM

Ya-Tzu Li

May 213 min read

GPCR Articles

Dynamic GPCR activation revealed through time-resolved Cryo-EM

Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the external environment. These...

John Teye Azietaku

May 144 min read

GPCR Articles

Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling

G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular signals, including hormones,...

Monserrat Avila-Zozaya

Apr 164 min read

GPCR Articles

From DNA day to GPCR genomics

April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure in 1953 and the completion of...

Inês Pinheiro

Apr 25 min read

GPCR Articles

GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions

GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations that recruit and ultimately...

Monserrat Avila-Zozaya

Mar 55 min read

GPCR Articles

An overview of the compartmentalized GPCR Signaling: Relevance and Implications

When it comes to signal transduction, cellular context matters. The cellular context is crucial for understanding the diverse signaling...

Inês Pinheiro

Jan 94 min read

GPCR Articles

Chemokine receptor-targeted drug discovery: progress and challenges

The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious diseases (Proudfoot 2002), and in...