Blog: Blog2

GPCR News

Nov 1, 20234 min read

Targeting Intracellular Allosteric Sites in GPCRs

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families of cell surface receptors, playing...

Monserrat Avila-Zozaya

Sep 26, 20234 min read

GPCR Articles

Nanobodies: New Dimensions in GPCR Signaling Research

Nanobodies (Nbs), known as variable antigen-binding (VHH) domain or single-domain antibodies, are small antigen-binding fragments. Nbs...

Inês Pinheiro

Aug 21, 20235 min read

GPCR Articles

Decoding β-Arrestins: from Structure to function

Fine-tuning GPCR signaling: conformational dynamics and intracellular responses GPCR signaling is a complex process modulated by protein...

Inês Pinheiro

Jun 28, 20237 min read

GPCR Articles

Structural landscape of the Chemokine Receptor system

Chemokine receptors (CKRs) belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial role in inflammation and...

Monserrat Avila-Zozaya

May 26, 20233 min read

GPCR Articles

Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation

At the cellular level, the plasmatic membrane is a thin layer of lipids that surrounds the entire cell allowing the differentiation...

Inês Pinheiro

May 16, 20235 min read

GPCR Articles

Artificial intelligence – faster, smarter, cheaper GPCR drug discovery

Artificial intelligence - Machine learning vs Deep Learning GPCRs have long been recognized as important drug targets, and numerous drugs...

Monserrat Avila-Zozaya

Apr 21, 20233 min read

GPCR Articles

VAMP2: a crucial player in the delivery of MOR to the synapse

Transporting Protein-coupled receptors (GPCRs) to the synapse, where they are involved in neurotransmission, is a complex process...

Inês Pinheiro

Apr 11, 20234 min read

GPCR Articles

Feeder or trigger – CCR2 as a scavenger and regulator of cell migration

Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon interaction with their cognate...

Monserrat Avila-Zozaya

Mar 2, 20233 min read

GPCR Articles

Regulators of G-protein signaling: essential players in GPCR signaling

Regulator G protein Signaling (RGS) proteins are critical components of the intracellular signaling pathways that mediate the effects of...

Inês Pinheiro

Feb 23, 20234 min read

GPCR Articles

Glyco-sulfo hotspots in the chemokine receptor system

Glycosylation and sulfation – N-terminal PTMs on chemokine receptors The interaction of chemokine receptors with their cognate chemokine...

Monserrat Avila-Zozaya

Feb 13, 20233 min read

GPCR Articles

New role of β-arrestins in MOR signaling

With around 187 people dying every day from an opioid overdose in the U.S., combatting the opioid overdose epidemic has become a mean...

Unlocking the Therapeutic Potential of Previously Undruggable GPCRs

Orion Biotechnology

Feb 1, 202310 min read

GPCR Articles

Unlocking the Therapeutic Potential of Previously Undruggable GPCRs

Executive Summary This whitepaper will provide an overview of G Protein-Coupled Receptors (GPCRs) and discuss current trends in GPCR drug...

Inês Pinheiro

Jan 13, 20234 min read

GPCR Articles

Odorant receptors – a bit of smell for drug discovery

Odorant receptors function and expression landscape Odorant receptors (ORs) belong to the G protein-coupled receptor (GPCR) family and...

Monserrat Avila-Zozaya

Dec 18, 20224 min read

GPCR Articles

Overview of adhesion GPCRs self-activation

Among the different families of G-protein-coupled receptors (GPCRs), adhesion GPCRs (aGPCRs) represent the second most abundant in humans....

Inês Pinheiro

Dec 6, 20223 min read

GPCR Articles

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery G-protein-coupled receptors (GPCRs) can form biologically...

Nipuna Weerasinghe

Nov 14, 20228 min read

GPCR Articles

Ode to GPCRs

Every year, with the month of October, comes the excitement of the Nobel session to the global scientific community. In the first few...

Monserrat Avila-Zozaya

Sep 20, 20222 min read

GPCR Articles

TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi

What is the molecular basis that determines that GPCRs bind selectively or promiscuously to different G proteins?. This question led...

Inês Pinheiro

Sep 20, 20223 min read

GPCR Articles

Therapeutic validation of an orphan G protein‐coupled receptor

Historically, ligands for GPCRs have been identified before their receptor counterparts. With the cloning revolution, several...