Diversity and specificity in location-based signaling outputs of neuronal GPCRs
August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the...
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GPCR News
Jul 31, 20221 min read
Posttranslational modifications in GPCR internalization
August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug...
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GPCR News
Jul 31, 20221 min read
Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
August 2022 "The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system, which...
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GPCR News
Jul 31, 20221 min read
In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells and tissues...
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GPCR News
Jul 31, 20221 min read
GRK2 in cardiovascular disease and its potential as a therapeutic target
August 2022 "Cardiovascular diseases (CVDs) represent the leading cause of death globally. Despite major advances in the field of...
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GPCR News
Jul 31, 20221 min read
Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
August 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells...
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GPCR News
Jul 31, 20221 min read
TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment...
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GPCR News
Jul 31, 20221 min read
Adenosine receptor signalling in Alzheimer's disease
August 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment...
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GPCR News
Jul 31, 20221 min read
Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies
August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric...
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GPCR News
Jul 31, 20221 min read
Exploring pharmacological inhibition of G q/11 as an analgesic strategy
August 2022 "Background and purpose: Misuse of opioids has greatly affected our society. One potential solution is to develop analgesics...
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GPCR News
Jul 31, 20221 min read
Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares
August 2022 "August 10, 2022 Cancer Research UK is working with global biopharma Sosei Heptares on a treatment they hope will bring...
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GPCR News
Jul 31, 20221 min read
Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for...
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GPCR News
Jul 31, 20221 min read
Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
August 2022 Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in Schizophrenia "BOSTON--(BUSINESS...
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GPCR News
Jul 31, 20221 min read
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
August 2022 "The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based...
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GPCR News
Jul 31, 20221 min read
Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G...
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GPCR News
Jul 31, 20221 min read
Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states....
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GPCR News
Jul 31, 20221 min read
4GPCRnet, September 26-29, 2022. Leipzig, Germany
August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for a joint meeting in Leipzig. Four...
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GPCR News
Jul 31, 20221 min read
Discovery On Target, October 17-20, 2022, Boston, USA
August 2022 "Join Us in Boston for Discovery On Target 2022! Discovery on Target (DOT) highlights advances in current and emerging “hot”...
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GPCR News
Jul 31, 20221 min read
Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
August 2022 "The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia, is due to mutations...
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GPCR News
Jul 31, 20221 min read
GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated with the pathophysiology of...
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