ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated ...
January 2022 ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated Vasculitis "SAN CARLOS,...
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GPCR News
Jan 1, 20221 min read
Learn more about Neurocrine Biosciences with their new video
January 2022 "The Neurocrine Biosciences story puts into words what makes the work and people at Neurocrine Biosciences so special. It...
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GPCR News
Jan 1, 20221 min read
Verily links up with Sosei Heptares for GPCR drug discovery
January 2022 "G-protein-coupled receptors’ star has been on the rise in biotech in recent years as researchers have discovered the vast...
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GPCR News
Jan 1, 20221 min read
ShouTi Pharma has a brand new website
January 2022 "We are an experienced, innovative, global team on a bold mission to improve health by creating and developing life-changing...
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GPCR News
Jan 1, 20221 min read
Inversago Pharma Completes Phase 1 Clinical Trial on First-in-Class, Peripheral CB1 Blocker and...
January 2022 Inversago Pharma Completes Phase 1 Clinical Trial on First-in-Class, Peripheral CB1 Blocker and Provides Strategy Update...
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GPCR News
Jan 1, 20221 min read
Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
January 2022 "OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Exscientia as Chief Scientist of...
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GPCR News
Jan 1, 20221 min read
Drug Discovery Picks Up the Pace, Stays on Target
January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time.” However, in drug discovery...
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GPCR News
Dec 31, 20211 min read
Learn more about Neurocrine Biosciences with their new video
January 2022 "The Neurocrine Biosciences story puts into words what makes the work and people at Neurocrine Biosciences so special. It...
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GPCR News
Dec 31, 20211 min read
A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent ...
A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in rat striatal neurons The activity...
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GPCR News
Dec 29, 20211 min read
Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of ...
Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4 WHIM...
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GPCR News
Dec 29, 20211 min read
Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a group of hereditary degenerative diseases affecting 1 of 4000 people worldwide and being the most...
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GPCR News
Dec 29, 20211 min read
Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E,
"Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for preventing cognitive dysfunction. We uncovered a...
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GPCR News
Dec 28, 20212 min read
Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes: Impact of ligand type and receptor activation...
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GPCR News
Dec 27, 20211 min read
Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
Intracellular calcium ([Ca2+]i) signaling is a critical regulator of chondrogenesis, chondrocyte differentiation, and cartilage...
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GPCR News
Dec 27, 20211 min read
Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...
Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall webworm Hyphantria cunea Background: Insect G...
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GPCR News
Dec 27, 20212 min read
Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates their affinity for bound ligands....
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GPCR News
Dec 26, 20211 min read
G-protein-coupled receptors as therapeutic targets for glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Treatments include surgical resection,...
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GPCR News
Dec 23, 20211 min read
Precise druggability of the PTH type 1 receptor
Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because their large orthosteric...
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GPCR News
Dec 22, 20211 min read
A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled receptors (GPCRs)....
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GPCR News
Dec 21, 20211 min read
Phospholipid Scrambling by G Protein-Coupled Receptors
Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for many aspects of cellular life. The...
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