Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors G...
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GPCR News
Dec 20, 20211 min read
Prostaglandin signaling in ciliogenesis and development
Prostaglandin (PG) signaling regulates a wide variety of physiological and pathological processes, including body temperature,...
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GPCR News
Dec 20, 20212 min read
Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
In presynaptic terminals, membrane-delimited Gi/o-mediated presynaptic inhibition is ubiquitous and acts through Gβγ to inhibit Ca2+...
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GPCR News
Dec 17, 20211 min read
Applications of Cryo-EM in small molecule and biologics drug design
Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological macromolecules, enabling...
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GPCR News
Dec 17, 20212 min read
HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
The hepatitis B virus X protein (HBx) is involved in the process of hepatocellular carcinoma via the activation of various oncogenes. Our...
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GPCR News
Dec 16, 20211 min read
Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
The physiological mechanisms driving synapse formation are elusive. Although numerous signals are known to regulate synapses, it remains...
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GPCR News
Dec 13, 20211 min read
GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably...
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GPCR News
Dec 13, 20211 min read
GPCR voltage dependence controls neuronal plasticity and behavior
G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions. Almost 20 years ago, GPCR activity was shown to be...
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GPCR News
Dec 12, 20211 min read
Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain. Pain may...
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GPCR News
Dec 11, 20211 min read
A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the...
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GPCR News
Dec 10, 20211 min read
The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...
The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in discrimination of closely related...
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GPCR News
Dec 9, 20211 min read
Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer...
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GPCR News
Dec 9, 20212 min read
Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the...
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GPCR News
Dec 9, 20211 min read
Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with...
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GPCR News
Dec 9, 20211 min read
G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
G protein-coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a The growth hormone...
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GPCR News
Dec 8, 20212 min read
The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo infection via distinct components...
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GPCR News
Dec 6, 20211 min read
Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver...
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GPCR News
Dec 6, 20212 min read
Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability Intrinsic...
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GPCR News
Dec 6, 20211 min read
In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine D1R, D2LR, D3R, and D4R,...
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GPCR News
Dec 6, 20211 min read
Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra
G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric...
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