G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways,...
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GPCR News
Sep 30, 20221 min read
Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting...
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GPCR News
Sep 1, 20221 min read
Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
September 2022 Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells transfected with their...
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GPCR News
Aug 31, 20221 min read
Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
September 2022 Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging...
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GPCR News
Aug 31, 20221 min read
Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different...
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GPCR News
Aug 31, 20221 min read
Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
September 2022 Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of...
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GPCR News
Aug 31, 20221 min read
Chemerin Forms: Their Generation and Activity
September 2022 "Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is...
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GPCR News
Aug 31, 20221 min read
PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors inhibits the...
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GPCR News
Aug 31, 20221 min read
CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling...
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GPCR News
Aug 31, 20221 min read
G protein coupling and activation of the metabotropic GABAB heterodimer
September 2022 "Metabotropic γ-aminobutyric acid receptor (GABABR), a class C G protein-coupled receptor (GPCR) heterodimer, plays a...
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GPCR News
Aug 31, 20221 min read
GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3...
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GPCR News
Aug 31, 20221 min read
Neurotransmitters: Potential Targets in Glioblastoma
September 2022 "For decades, glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has remained a formidable challenge in...
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GPCR News
Aug 31, 20221 min read
GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and...
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GPCR News
Aug 31, 20221 min read
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
September 2022 Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding...
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GPCR News
Aug 31, 20222 min read
Platelets in the NETworks interweaving inflammation and thrombosis
September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. Research over...
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GPCR News
Aug 31, 20221 min read
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
September 2022 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases...
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GPCR News
Aug 31, 20221 min read
Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by...
September 2022 Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil...
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GPCR News
Aug 31, 20221 min read
C5aR2 receptor: The genomic twin of the flamboyant C5aR1
September 2022 "The complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the...
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GPCR News
Aug 31, 20221 min read
C1-inhibitor influence on platelet activation by thrombin receptors agonists
September 2022 "Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet activation. Data on...
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GPCR News
Aug 31, 20221 min read
Residency time of agonists does not affect the stability of GPCR-arrestin complexes
September 2022 "Background and purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs) desensitizes...
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