GPCR News 

Targeting Intracellular Allosteric Sites in GPCRs

Decoding β-Arrestins: from Structure to function

Structural landscape of the Chemokine Receptor system

Artificial intelligence – faster, smarter, cheaper GPCR drug discovery

VAMP2: a crucial player in the delivery of MOR to the synapse

Feeder or trigger – CCR2 as a scavenger and regulator of cell migration

Glyco-sulfo hotspots in the chemokine receptor system

Odorant receptors – a bit of smell for drug discovery

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery

Emerging approaches for decoding neuropeptide transmission

Location bias contributes to functionally selective responses of biased CXCR3 agonists

Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors

Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...

Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures