Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle...
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GPCR News
Aug 31, 20221 min read
Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy...
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GPCR News
Aug 31, 20221 min read
Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas...
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GPCR News
Aug 31, 20222 min read
Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor
September 2022 "The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs),...
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GPCR News
Aug 31, 20221 min read
Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug...
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GPCR News
Aug 31, 20221 min read
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced...
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GPCR News
Aug 31, 20221 min read
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all aspects of neuronal...
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GPCR News
Aug 31, 20221 min read
Identification of hub genes in the subacute spinal cord injury in rats
September 2022 "Background Spinal cord injury (SCI) is a common trauma in clinical practices. Subacute SCI is mainly characterized by...
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GPCR News
Aug 31, 20221 min read
Endogenous ligand recognition and structural transition of a human PTH receptor
September 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R)...
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GPCR News
Aug 31, 20221 min read
CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert...
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GPCR News
Aug 31, 20221 min read
Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
September 2022 "Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and...
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GPCR News
Aug 31, 20221 min read
PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of...
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GPCR News
Aug 31, 20221 min read
Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating...
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GPCR News
Aug 31, 20221 min read
Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to...
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GPCR News
Aug 31, 20221 min read
Arginine 125 Is an Essential Residue for the Function of MRAP2
September 2022 "MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is...
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GPCR News
Aug 31, 20221 min read
Immunomodulatory Role of Neuropeptides in the Cornea
September 2022 "The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an...
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GPCR News
Aug 31, 20221 min read
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and...
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GPCR News
Aug 31, 20221 min read
Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative...
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GPCR News
Aug 31, 20221 min read
GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization, internalization, and...
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GPCR News
Aug 31, 20222 min read
The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
September 2021 "Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two...
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