Jan Steyaert Named 2022 Jacob and Louise Gabbay Award Winner
August 2022 "August 12, 2022.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut...
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GPCR News
Jul 31, 20221 min read
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
August 2022 "Three classes of G-protein-coupled receptor (GPCR) partners - G proteins, GPCR kinases, and arrestins - preferentially bind...
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GPCR News
Jul 31, 20221 min read
Amgen to Acquire Chemocentryx for $4 Billion in Cash
August 2022 "THOUSAND OAKS, Calif. and SAN CARLOS, Calif., Aug. 4, 2022 /PRNewswire/ -- Amgen (NASDAQ: AMGN) and ChemoCentryx, Inc.,...
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GPCR News
Jul 31, 20221 min read
Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
August 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis...
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GPCR News
Jul 31, 20221 min read
GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin...
August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors "Serotonin (or...
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GPCR News
Jul 31, 20221 min read
Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
August 2022 Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for Substance Use Disorders "Geneva,...
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GPCR News
Jul 31, 20221 min read
Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
August 2022 Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus...
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GPCR News
Jul 31, 20221 min read
The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor
August 2022 "Background: Activation of signaling effectors by G-protein coupled receptors (GPCRs) depends on different molecular...
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GPCR News
Jul 31, 20221 min read
G protein-coupled receptor 21 in macrophages: An in vitro study
August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein Coupled Receptors (GPCRs)....
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GPCR News
Jul 31, 20221 min read
MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various biologic processes and regulation of...
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GPCR News
Jul 31, 20221 min read
Fusion protein strategies for cryo-EM study of G protein-coupled receptors
August 2022 "Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G...
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GPCR News
Jul 31, 20221 min read
Addex Reports 2022 Half Year and Second Quarter Financial Results and Provides Corporate Update
August 2022 "Geneva, Switzerland, August 18, 2022 - Addex Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company...
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GPCR News
Jul 31, 20222 min read
GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic...
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GPCR News
Jul 31, 20221 min read
Diversity and specificity in location-based signaling outputs of neuronal GPCRs
August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the...
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GPCR News
Jul 31, 20221 min read
Posttranslational modifications in GPCR internalization
August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug...
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GPCR News
Jul 31, 20221 min read
Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
August 2022 "The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system, which...
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GPCR News
Jul 31, 20221 min read
In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells and tissues...
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GPCR News
Jul 31, 20221 min read
GRK2 in cardiovascular disease and its potential as a therapeutic target
August 2022 "Cardiovascular diseases (CVDs) represent the leading cause of death globally. Despite major advances in the field of...
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GPCR News
Jul 31, 20221 min read
Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
August 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells...
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GPCR News
Jul 31, 20221 min read
TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment...
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