To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
September 2022 To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from inactive conformation...
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GPCR News
Aug 31, 20221 min read
Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients
September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver...
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GPCR News
Aug 31, 20222 min read
β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced...
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GPCR News
Aug 31, 20221 min read
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...
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GPCR News
Aug 31, 20221 min read
Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
September 2022 "The function of the actin cytoskeleton in cellular motility and trafficking has been widely studied. However,...
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GPCR News
Aug 31, 20221 min read
Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and...
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GPCR News
Aug 31, 20221 min read
Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under...
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GPCR News
Aug 31, 20222 min read
Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction...
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GPCR News
Aug 31, 20221 min read
Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
September 2022 Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits "Although the...
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GPCR News
Aug 31, 20221 min read
A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
September 2022 "Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy...
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GPCR News
Aug 31, 20221 min read
A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New..
September 2022 A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3...
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GPCR News
Aug 31, 20221 min read
Functional modulation of PTH1R activation and signaling by RAMP2
September 2022 "Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate with different G...
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GPCR News
Aug 31, 20221 min read
High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient...
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GPCR News
Aug 31, 20221 min read
Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
September 2022 "Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize an active conformation of class A...
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GPCR News
Aug 31, 20221 min read
A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation, vasculopathy and...
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GPCR News
Aug 31, 20221 min read
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and...
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GPCR News
Aug 31, 20221 min read
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
September 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages "The...
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GPCR News
Aug 31, 20221 min read
Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
September 2022 Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its interactions with...
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GPCR News
Aug 31, 20221 min read
Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
September 2022 Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized...
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GPCR News
Aug 31, 20222 min read
Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer...
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