AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range of physiological...
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GPCR News
Jul 31, 20221 min read
Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
August 2022 "Abstract The β3 -adrenergic receptor (β3 -AR) is found in several tissues such as adipose tissue and urinary bladder. It is...
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GPCR News
Jul 31, 20221 min read
RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
August 2022 RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany. Hybrid meeting. "Dear Sir...
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GPCR News
Jul 31, 20221 min read
SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
August 2022 "We are proud to announce that SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
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GPCR News
Jul 31, 20221 min read
Molecular targets of psychedelic-induced plasticity
August 2022 "Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the...
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GPCR News
Jul 31, 20221 min read
Molecular insights into psychedelic drug action
August 2022 "A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic...
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GPCR News
Jul 31, 20221 min read
Multifunctional role of GPCR signaling in epithelial tube formation
August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive cell...
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GPCR News
Jul 31, 20221 min read
Trevena Reports Second Quarter 2022 Results and Provides Business Update
August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the...
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GPCR News
Jul 31, 20221 min read
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1
August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells...
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GPCR News
Jul 31, 20221 min read
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting
August 2022 GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order...
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GPCR News
Jul 31, 20221 min read
A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living...
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GPCR News
Jul 31, 20221 min read
2nd IRN i-GPCRnet, September 30 to October 1st, 2022. University of Wurzburg, Germany
August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from...
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GPCR News
Jul 31, 20221 min read
Effects of Small Molecule Ligands on ACKR3 Receptors
August 2022 "Abstract Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the...
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GPCR News
Jul 31, 20221 min read
Community guidelines for GPCR ligand bias: IUPHAR review 32
August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending...
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GPCR News
Jul 31, 20221 min read
A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
August 2022 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor...
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GPCR News
Jul 31, 20221 min read
Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic reticulum membrane...
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GPCR News
Jul 31, 20221 min read
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and...
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GPCR News
Jul 31, 20221 min read
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully...
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GPCR News
Jul 31, 20221 min read
Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), which ought to facilitate...
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GPCR News
Jul 31, 20221 min read
GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
August 2022 "Bone remodeling is precisely regulated mainly by osteoblasts and osteoclasts. Although some G-protein coupled receptors...
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