GPCR News 

Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...

The complicated lives of GPCRs in cardiac fibroblasts

Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice

Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair

GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP

GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...

The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane

Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...

Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...

Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890

N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...

GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...

PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Single-molecule counting applied to the study of GPCR oligomerization

Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...

Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors

Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...