Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling
October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors...
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GPCR News
Sep 30, 20221 min read
Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression "Kaixinsan...
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GPCR News
Sep 30, 20221 min read
Diversification of PAR signaling through receptor crosstalk
October 2022 "Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these...
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GPCR News
Sep 30, 20221 min read
Comparative study of neuropeptide signaling systems in Hemiptera
October 2022 "Numerous physiological processes in insects are tightly regulated by neuropeptides and their receptors. Although they form...
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GPCR News
Sep 30, 20221 min read
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through...
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GPCR News
Sep 30, 20221 min read
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist...
October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation...
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GPCR News
Sep 30, 20221 min read
A cryptic mode of GPCR regulation revealed
October 2022 "Over three decades of research have provided thorough insights into G protein-coupled receptor (GPCR) regulation. In a...
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GPCR News
Sep 30, 20221 min read
Design and validation of recombinant protein standards for quantitative Western blot analysis of...
October 2022 Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor...
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GPCR News
Sep 30, 20222 min read
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
October 2022 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal...
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GPCR News
Sep 30, 20221 min read
Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
October 2022 Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR...
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GPCR News
Sep 30, 20221 min read
Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised,...
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GPCR News
Sep 30, 20221 min read
The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function and synaptic plasticity. Microglia...
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GPCR News
Sep 30, 20222 min read
Co-activation of GPCRs facilitate GIRK-dependent current
October 2022 "The activity of dopamine neurons is dependent on both intrinsic properties and afferent projections. One potent form of...
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GPCR News
Sep 30, 20221 min read
Label-free LC-MS based assay to characterize small molecule compound binding to cells
October 2022 "Study of small molecule binding to live cells provides important information on the characterization of ligands...
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GPCR News
Sep 30, 20221 min read
Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
October 2022 Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes...
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GPCR News
Sep 30, 20221 min read
G protein-coupled receptor signaling: transducers and effectors
October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological...
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GPCR News
Sep 30, 20221 min read
Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
October 2022 "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that...
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GPCR News
Sep 30, 20221 min read
Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis "Organ...
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GPCR News
Sep 30, 20221 min read
The regulation of PKA signaling in obesity and in the maintenance of metabolic health
October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway throughout systems and across...
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GPCR News
Sep 30, 20221 min read
Protein Uncoupling as an Innovative Practice in Diabetes Mellitus Treatment: A Metabolic Disorder
October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport...
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