Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
September 2022 Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury...
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GPCR News
Aug 31, 20221 min read
Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
September 2022 "RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter protein function through...
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GPCR News
Aug 31, 20221 min read
PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal...
September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells "A novel mast...
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GPCR News
Aug 31, 20222 min read
Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein) plays a crucial role in the...
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GPCR News
Aug 31, 20221 min read
Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
September 2022 "Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in retinal rod and cone photoreceptor...
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GPCR News
Aug 31, 20221 min read
Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
September 2022 Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis by Repurposing...
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GPCR News
Aug 31, 20221 min read
The expression and clinical significance of GPR39 in colon cancer
September 2022 "Background: Colorectal cancer is the third most common cancer and requires more prognostic biomarkers for precise...
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GPCR News
Aug 31, 20221 min read
Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
September 2022 "Yeast use the G-protein–coupled receptor signaling pathway to detect and track the mating pheromone. The...
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GPCR News
Aug 31, 20221 min read
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
September 2022 "Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental...
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GPCR News
Aug 31, 20222 min read
Interacting binding insights and conformational consequences of the differential activity of...
September 2022 Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two...
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GPCR News
Aug 31, 20221 min read
Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
September 2022 "Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies that include retinitis...
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GPCR News
Aug 31, 20221 min read
Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
September 2022 Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A...
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GPCR News
Aug 31, 20221 min read
The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated...
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GPCR News
Aug 31, 20221 min read
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target in...
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GPCR News
Aug 31, 20221 min read
C3aR plays both sides in regulating resistance to bacterial infections
September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which...
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GPCR News
Aug 31, 20221 min read
Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle...
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GPCR News
Aug 31, 20221 min read
Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy...
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GPCR News
Aug 31, 20221 min read
Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas...
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GPCR News
Aug 31, 20222 min read
Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor
September 2022 "The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs),...
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GPCR News
Aug 31, 20221 min read
Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug...
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