Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced...
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GPCR News
Aug 31, 20221 min read
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all aspects of neuronal...
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GPCR News
Aug 31, 20221 min read
Identification of hub genes in the subacute spinal cord injury in rats
September 2022 "Background Spinal cord injury (SCI) is a common trauma in clinical practices. Subacute SCI is mainly characterized by...
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GPCR News
Aug 31, 20221 min read
Endogenous ligand recognition and structural transition of a human PTH receptor
September 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R)...
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GPCR News
Aug 31, 20221 min read
CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert...
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GPCR News
Aug 31, 20221 min read
Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
September 2022 "Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and...
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GPCR News
Aug 31, 20221 min read
PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of...
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GPCR News
Aug 31, 20221 min read
Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating...
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GPCR News
Aug 31, 20221 min read
Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to...
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GPCR News
Aug 31, 20221 min read
Arginine 125 Is an Essential Residue for the Function of MRAP2
September 2022 "MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is...
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GPCR News
Aug 31, 20221 min read
Immunomodulatory Role of Neuropeptides in the Cornea
September 2022 "The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an...
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GPCR News
Aug 31, 20221 min read
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and...
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GPCR News
Aug 31, 20221 min read
Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative...
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GPCR News
Aug 31, 20221 min read
GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization, internalization, and...
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GPCR News
Aug 31, 20222 min read
The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
September 2021 "Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two...
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GPCR News
Aug 31, 20221 min read
Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
September 2022 Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to...
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GPCR News
Aug 31, 20221 min read
Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
September 2022 Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted...
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GPCR News
Aug 1, 20221 min read
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype
August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets and...
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GPCR News
Aug 1, 20221 min read
In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
August 2022 In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-HT2A R...
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GPCR News
Jul 31, 20221 min read
Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
August 2022 "As the only member of the CX3C chemokine receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows...
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