A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
August 2022 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor...
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GPCR News
Jul 31, 20221 min read
Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic reticulum membrane...
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GPCR News
Jul 31, 20221 min read
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and...
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GPCR News
Jul 31, 20221 min read
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully...
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GPCR News
Jul 31, 20221 min read
Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), which ought to facilitate...
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GPCR News
Jul 31, 20221 min read
GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
August 2022 "Bone remodeling is precisely regulated mainly by osteoblasts and osteoclasts. Although some G-protein coupled receptors...
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GPCR News
Jul 31, 20221 min read
Helix 8 in chemotactic receptors of the complement system
August 2022 "Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a...
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GPCR News
Jul 31, 20221 min read
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through...
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GPCR News
Jul 31, 20221 min read
G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions and inflammation "G...
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GPCR News
Jul 31, 20221 min read
TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's...
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GPCR News
Jul 31, 20221 min read
Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic...
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GPCR News
Jul 31, 20221 min read
Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular...
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GPCR News
Jun 30, 20221 min read
G.CLIPS biotech is 2 years old this month!
July 2022 "G.CLIPS biotech is 2 years old today🎂. When I came this morning to work this is how I found my desk. So very grateful to the...
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GPCR News
Jun 30, 20221 min read
Exscientia is 10 years old this July!
July 2022 "Today we are celebrating ten years of Exscientia! Founded as a spinout from the University of Dundee on 20 July 2012,...
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GPCR News
Jun 30, 20221 min read
X4 slashes pipeline, lays off staff just three weeks after netting a $55M PIPE
July 2022 "Not even a PIPE financing could save X4 Pharmaceuticals from enacting layoffs and trimming its pipeline. The Boston biotech...
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GPCR News
Jun 30, 20221 min read
Dr. Ross Bathgate becomes Scientific co-founder of LASEREDD Therapeutics
July 2022 "I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics" Ross Bathgate Read more at...
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GPCR News
Jun 30, 20221 min read
Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators for ...
July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators for rare diseases "29/06/2022...
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GPCR News
Jun 30, 20221 min read
Sosei Heptares recently hosted their annual Scientific Advisory Board (SAB)
"We recently hosted our annual Scientific Advisory Board (SAB) summit at our site within Granta Park. It was great to bring everyone...
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GPCR News
Jun 30, 20221 min read
Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
July 2022 "Orion Biotechnology and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical space and...
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GPCR News
Jun 30, 20221 min read
Tectonic Therapeutic Strengthens Leadership Team
July 2022 "July 19, 2022 07:00 AM Eastern Daylight Time BOSTON--Tectonic Therapeutic, Inc. a pre-clinical stage biotechnology company...
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