Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat...
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GPCR News
Sep 30, 20221 min read
Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
October 2022 "Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved...
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GPCR News
Sep 30, 20221 min read
Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
October 2022 "Understanding the activation of G protein-coupled receptors (GPCRs) is of paramount importance to the field of...
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GPCR News
Sep 30, 20221 min read
Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various...
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GPCR News
Sep 30, 20221 min read
Endosomal parathyroid hormone receptor signaling
October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation of heterotrimeric G protein...
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GPCR News
Sep 30, 20221 min read
Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
October 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells...
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GPCR News
Sep 30, 20221 min read
Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of the prime targets for marketed...
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GPCR News
Sep 30, 20221 min read
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
October 2022 Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin...
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GPCR News
Sep 30, 20221 min read
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein coupled...
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GPCR News
Sep 30, 20221 min read
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
October 2022 GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor...
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GPCR News
Sep 30, 20221 min read
Endogenous ligand recognition and structural transition of a human PTH receptor
October 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R) and...
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GPCR News
Sep 30, 20221 min read
Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
October 2022 Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception "Pain...
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GPCR News
Sep 30, 20221 min read
Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
October 2022 Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics...
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GPCR News
Sep 30, 20221 min read
ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the...
October 2022 ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP...
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GPCR News
Sep 30, 20221 min read
Adenosine receptor signalling in Alzheimer's disease
October 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment...
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GPCR News
Sep 30, 20221 min read
Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
October 2022 Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A...
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GPCR News
Sep 30, 20221 min read
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial...
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GPCR News
Sep 30, 20221 min read
Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
October 2022 Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of Adhesion Receptor GPR97...
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GPCR News
Sep 30, 20221 min read
Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR) for 19F-NMR...
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GPCR News
Sep 30, 20222 min read
Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
October 2022 Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein...
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