Multifunctional role of GPCR signaling in epithelial tube formation
September 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive...
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GPCR News
Aug 31, 20221 min read
Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
September 2022 "Evaluation of stimulus salience is critical for any higher organism, as it allows for prioritizing of vital information,...
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GPCR News
Aug 31, 20221 min read
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of...
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GPCR News
Aug 31, 20221 min read
Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration...
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GPCR News
Aug 31, 20221 min read
Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
September 2022 "The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous peptide GPR15L(25-81) and...
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GPCR News
Aug 31, 20221 min read
Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
September 2022 Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs) Harboring Oncogenic...
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GPCR News
Aug 31, 20221 min read
Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs...
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GPCR News
Aug 31, 20221 min read
Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
September 2022 "The diamondback moth (Plutella xylostella) is one of the most destructive lepidopteran pests of cruciferous vegetables,...
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GPCR News
Aug 31, 20221 min read
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors (GPCRs), mechanistic...
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GPCR News
Aug 31, 20221 min read
Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
September 2022 "Pregnant and lactating women have been discouraged from using cannabis by Health Canada. However, the increasing rate of...
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GPCR News
Aug 31, 20221 min read
GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious...
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GPCR News
Aug 31, 20221 min read
Hear the sounds: the role of G protein-coupled receptors in the cochlea
September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted by spiral ganglion neurons...
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GPCR News
Aug 31, 20221 min read
FSH and bone: Comparison between males with central versus primary hypogonadism
September 2022 "Experimental studies proposed a direct effect of follicle-stimulating hormone (FSH) on the skeletal metabolism, but...
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GPCR News
Aug 31, 20221 min read
To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
September 2022 To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from inactive conformation...
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GPCR News
Aug 31, 20221 min read
Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients
September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver...
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GPCR News
Aug 31, 20222 min read
β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced...
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GPCR News
Aug 31, 20221 min read
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...
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GPCR News
Aug 31, 20221 min read
Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
September 2022 "The function of the actin cytoskeleton in cellular motility and trafficking has been widely studied. However,...
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GPCR News
Aug 31, 20221 min read
Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and...
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GPCR News
Aug 31, 20221 min read
Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under...
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