Adenosine receptor signalling in Alzheimer's disease
August 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment...
top of page
Ecosystem
Beta Site
Blog: Blog2
GPCR News
Search
GPCR News
Jul 31, 20221 min read
Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies
August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric...
10
GPCR News
Jul 31, 20221 min read
Exploring pharmacological inhibition of G q/11 as an analgesic strategy
August 2022 "Background and purpose: Misuse of opioids has greatly affected our society. One potential solution is to develop analgesics...
620
GPCR News
Jul 31, 20221 min read
Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares
August 2022 "August 10, 2022 Cancer Research UK is working with global biopharma Sosei Heptares on a treatment they hope will bring...
60
GPCR News
Jul 31, 20221 min read
Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for...
60
GPCR News
Jul 31, 20221 min read
Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
August 2022 Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in Schizophrenia "BOSTON--(BUSINESS...
40
GPCR News
Jul 31, 20221 min read
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
August 2022 "The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based...
40
GPCR News
Jul 31, 20221 min read
Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G...
10
GPCR News
Jul 31, 20221 min read
Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states....
20
GPCR News
Jul 31, 20221 min read
4GPCRnet, September 26-29, 2022. Leipzig, Germany
August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for a joint meeting in Leipzig. Four...
20
GPCR News
Jul 31, 20221 min read
Discovery On Target, October 17-20, 2022, Boston, USA
August 2022 "Join Us in Boston for Discovery On Target 2022! Discovery on Target (DOT) highlights advances in current and emerging “hot”...
60
GPCR News
Jul 31, 20221 min read
Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
August 2022 "The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia, is due to mutations...
10
GPCR News
Jul 31, 20221 min read
GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated with the pathophysiology of...
50
GPCR News
Jul 31, 20221 min read
AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range of physiological...
30
GPCR News
Jul 31, 20221 min read
Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
August 2022 "Abstract The β3 -adrenergic receptor (β3 -AR) is found in several tissues such as adipose tissue and urinary bladder. It is...
30
GPCR News
Jul 31, 20221 min read
RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
August 2022 RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany. Hybrid meeting. "Dear Sir...
10
GPCR News
Jul 31, 20221 min read
SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
August 2022 "We are proud to announce that SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
60
GPCR News
Jul 31, 20221 min read
Molecular targets of psychedelic-induced plasticity
August 2022 "Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the...
40
GPCR News
Jul 31, 20221 min read
Molecular insights into psychedelic drug action
August 2022 "A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic...
30
GPCR News
Jul 31, 20221 min read
Multifunctional role of GPCR signaling in epithelial tube formation
August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive cell...
10
bottom of page