Trevena Reports Second Quarter 2022 Results and Provides Business Update
August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the...
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Jul 31, 20221 min read
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1
August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells...
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GPCR News
Jul 31, 20221 min read
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting
August 2022 GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order...
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GPCR News
Jul 31, 20221 min read
A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living...
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GPCR News
Jul 31, 20221 min read
2nd IRN i-GPCRnet, September 30 to October 1st, 2022. University of Wurzburg, Germany
August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from...
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Jul 31, 20221 min read
Effects of Small Molecule Ligands on ACKR3 Receptors
August 2022 "Abstract Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the...
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GPCR News
Jul 31, 20221 min read
Community guidelines for GPCR ligand bias: IUPHAR review 32
August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending...
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GPCR News
Jul 31, 20221 min read
A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
August 2022 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor...
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GPCR News
Jul 31, 20221 min read
Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic reticulum membrane...
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GPCR News
Jul 31, 20221 min read
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and...
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GPCR News
Jul 31, 20221 min read
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully...
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GPCR News
Jul 31, 20221 min read
Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), which ought to facilitate...
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GPCR News
Jul 31, 20221 min read
GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
August 2022 "Bone remodeling is precisely regulated mainly by osteoblasts and osteoclasts. Although some G-protein coupled receptors...
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GPCR News
Jul 31, 20221 min read
Helix 8 in chemotactic receptors of the complement system
August 2022 "Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a...
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GPCR News
Jul 31, 20221 min read
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through...
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GPCR News
Jul 31, 20221 min read
G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions and inflammation "G...
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GPCR News
Jul 31, 20221 min read
TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's...
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GPCR News
Jul 31, 20221 min read
Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic...
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GPCR News
Jul 31, 20221 min read
Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular...
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GPCR News
Jun 30, 20221 min read
G.CLIPS biotech is 2 years old this month!
July 2022 "G.CLIPS biotech is 2 years old today🎂. When I came this morning to work this is how I found my desk. So very grateful to the...
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