Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
October 2022 Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A...
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GPCR News
Sep 30, 20221 min read
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial...
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GPCR News
Sep 30, 20221 min read
Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
October 2022 Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of Adhesion Receptor GPR97...
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GPCR News
Sep 30, 20221 min read
Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR) for 19F-NMR...
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GPCR News
Sep 30, 20222 min read
Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
October 2022 Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein...
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GPCR News
Sep 30, 20221 min read
Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
October 2022 Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in...
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GPCR News
Sep 30, 20221 min read
N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
October 2022 "Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases with high...
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GPCR News
Sep 30, 20221 min read
Function and structure of bradykinin receptor 2 for drug discovery
October 2022 "Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system...
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GPCR News
Sep 30, 20221 min read
Specific Functions of Melanocortin 3 Receptor (MC3R)
October 2022 "Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor (GPCR) that is defined as a regulator of appetite/hunger...
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GPCR News
Sep 30, 20221 min read
Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
October 2022 "Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune...
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GPCR News
Sep 30, 20221 min read
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
October 2022 β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells...
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GPCR News
Sep 30, 20221 min read
The complicated lives of GPCRs in cardiac fibroblasts
October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes...
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GPCR News
Sep 30, 20221 min read
Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
October 2022 "Psychedelics, also known as classical hallucinogens, affect processes related to perception, cognition and sensory...
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GPCR News
Sep 30, 20222 min read
Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair
October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction in cardiac function and still...
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GPCR News
Sep 30, 20221 min read
GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by proteolytic cleavage of its...
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GPCR News
Sep 30, 20222 min read
GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
October 2022 GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates...
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GPCR News
Sep 30, 20221 min read
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding...
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GPCR News
Sep 30, 20221 min read
Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of G-protein-coupled receptors...
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GPCR News
Sep 30, 20221 min read
The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the adhesion GPCR family. Mutations in...
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GPCR News
Sep 30, 20221 min read
Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in honeybee Apis mellifera: An...
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