Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
October 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia...
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GPCR News
Sep 30, 20221 min read
Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular signaling pathways. They can...
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GPCR News
Sep 30, 20221 min read
N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards...
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GPCR News
Sep 30, 20221 min read
GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
October 2022 GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium "The rheumatoid...
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GPCR News
Sep 30, 20221 min read
PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying signaling pathways are...
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GPCR News
Sep 30, 20221 min read
Single-molecule counting applied to the study of GPCR oligomerization
October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular abundance and stoichiometry of...
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GPCR News
Sep 30, 20221 min read
Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of Cannabinoid CB1 Receptor...
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GPCR News
Sep 30, 20221 min read
Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
October 2022 "The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other...
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GPCR News
Sep 30, 20221 min read
Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
October 2022 Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived G Protein Coupled...
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GPCR News
Sep 30, 20221 min read
Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling
October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors...
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GPCR News
Sep 30, 20221 min read
Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression "Kaixinsan...
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GPCR News
Sep 30, 20221 min read
Diversification of PAR signaling through receptor crosstalk
October 2022 "Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these...
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GPCR News
Sep 30, 20221 min read
Comparative study of neuropeptide signaling systems in Hemiptera
October 2022 "Numerous physiological processes in insects are tightly regulated by neuropeptides and their receptors. Although they form...
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GPCR News
Sep 30, 20221 min read
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through...
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GPCR News
Sep 30, 20221 min read
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist...
October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation...
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GPCR News
Sep 30, 20221 min read
A cryptic mode of GPCR regulation revealed
October 2022 "Over three decades of research have provided thorough insights into G protein-coupled receptor (GPCR) regulation. In a...
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GPCR News
Sep 30, 20221 min read
Design and validation of recombinant protein standards for quantitative Western blot analysis of...
October 2022 Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor...
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GPCR News
Sep 30, 20222 min read
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
October 2022 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal...
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GPCR News
Sep 30, 20221 min read
Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
October 2022 Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR...
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GPCR News
Sep 30, 20221 min read
Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised,...
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