GPCR News 

October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function and synaptic plasticity. Microglia...

October 2022 "The activity of dopamine neurons is dependent on both intrinsic properties and afferent projections. One potent form of...

October 2022 "Study of small molecule binding to live cells provides important information on the characterization of ligands...

October 2022 Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes...

October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological...

October 2022 "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that...

October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis "Organ...

October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway throughout systems and across...

October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport...

October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways,...

October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting...

What is the molecular basis that determines that GPCRs bind selectively or promiscuously to different G proteins?. This question led...

Historically, ligands for GPCRs have been identified before their receptor counterparts. With the cloning revolution, several...