Blog: Blog2

GPCR News

Aug 31, 20221 min read

Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...

September 2022 Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A...

GPCR News

Aug 31, 20221 min read

The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?

September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated...

GPCR News

Aug 31, 20221 min read

Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor

September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target in...

GPCR News

Aug 31, 20221 min read

C3aR plays both sides in regulating resistance to bacterial infections

September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which...

GPCR News

Aug 31, 20221 min read

Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...

September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle...

GPCR News

Aug 31, 20221 min read

Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy...

GPCR News

Aug 31, 20221 min read

Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas...

GPCR News

Aug 31, 20222 min read

Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor

September 2022 "The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs),...

GPCR News

Aug 31, 20221 min read

Combined docking and machine learning identify key molecular determinants of ligand pharmacological

September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug...

GPCR News

Aug 31, 20221 min read

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced...

GPCR News

Aug 31, 20221 min read

Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases

September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all aspects of neuronal...

GPCR News

Aug 31, 20221 min read

Identification of hub genes in the subacute spinal cord injury in rats

September 2022 "Background Spinal cord injury (SCI) is a common trauma in clinical practices. Subacute SCI is mainly characterized by...

GPCR News

Aug 31, 20221 min read

Endogenous ligand recognition and structural transition of a human PTH receptor

September 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R)...

GPCR News

Aug 31, 20221 min read

CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert...

GPCR News

Aug 31, 20221 min read

Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes

September 2022 "Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and...

GPCR News

Aug 31, 20221 min read

PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer

September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of...

GPCR News

Aug 31, 20221 min read

Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge

September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating...

GPCR News

Aug 31, 20221 min read

Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to...

GPCR News

Aug 31, 20221 min read

Arginine 125 Is an Essential Residue for the Function of MRAP2

September 2022 "MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is...

GPCR News

Aug 31, 20221 min read

Immunomodulatory Role of Neuropeptides in the Cornea

September 2022 "The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an...

GPCR News

Aug 31, 20221 min read

GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer

September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and...

GPCR News

Aug 31, 20221 min read

Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative...

GPCR News

Aug 31, 20221 min read

GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...

September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization, internalization, and...

GPCR News

Aug 31, 20222 min read

The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells

September 2021 "Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two...

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