GPCR News 

GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin...

Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...

Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di

The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor

G protein-coupled receptor 21 in macrophages: An in vitro study

MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Addex Reports 2022 Half Year and Second Quarter Financial Results and Provides Corporate Update

GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...

Diversity and specificity in location-based signaling outputs of neuronal GPCRs

Posttranslational modifications in GPCR internalization

Molecular basis for ligand modulation of the cannabinoid CB 1 receptor

In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors

GRK2 in cardiovascular disease and its potential as a therapeutic target

Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases

TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...

Adenosine receptor signalling in Alzheimer's disease

Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies

Exploring pharmacological inhibition of G q/11 as an analgesic strategy

Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares

Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2

Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...

Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept

Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet