Blog: Blog2

GPCR News

Dec 11, 20211 min read

A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the...

GPCR News

Dec 10, 20211 min read

GPCR Papers

The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...

The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in discrimination of closely related...

GPCR News

Dec 9, 20211 min read

GPCR Papers

Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation

Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer...

GPCR News

Dec 9, 20212 min read

GPCR Papers

Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..

Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the...

GPCR News

Dec 9, 20211 min read

GPCR Papers

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with...

GPCR News

Dec 9, 20211 min read

GPCR Papers

G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...

G protein-coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a The growth hormone...

GPCR News

Dec 8, 20212 min read

GPCR Papers

The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...

The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo infection via distinct components...

GPCR News

Dec 6, 20211 min read

GPCR Papers

Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...

Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver...

GPCR News

Dec 6, 20212 min read

GPCR Papers

Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...

Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability Intrinsic...

GPCR News

Dec 6, 20211 min read

GPCR Papers

In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...

Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine D1R, D2LR, D3R, and D4R,...

GPCR News

Dec 6, 20211 min read

GPCR Papers

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra

G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric...

GPCR News

Dec 6, 20211 min read

GPCR Papers

In vivo metabolic effects after acute activation of skeletal muscle G s signaling

Objective: The goal of this study was to determine the glucometabolic effects of acute activation of Gs signaling in skeletal muscle...

GPCR News

Dec 5, 20211 min read

GPCR Papers

Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...

Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function...

GPCR News

Dec 3, 20211 min read

GPCR Papers

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

G protein-coupled receptors (GPCRs) have been shown to play integral roles in Alzheimer's disease pathogenesis. However, it is unclear...

GPCR News

Dec 3, 20211 min read

GPCR Papers

Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and ...

Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimer Information flow from a source to a...

GPCR News

Dec 3, 20211 min read

GPCR Papers

G protein-coupled receptors that influence lifespan of human and animal models

Humanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G...

GPCR News

Dec 2, 20211 min read

GPCR Papers

Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans

Chemical communication controls a wide range of behaviors via conserved signaling networks. Axon regeneration in response to injury is...

GPCR News

Dec 2, 20211 min read

GPCR Papers

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide...

GPCR News

Dec 1, 20211 min read

GPCR Papers

Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors

"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in a variety of tissues. Crystal...

GPCR News

Dec 1, 20211 min read

GPCR Papers

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation G protein-coupled...

GPCR News

Dec 1, 20211 min read

GPCR Papers

SLAS2022 International Conference and Exhibition

"We are moving ahead with SLAS2022 as an in-person event with a hybrid component. We are closely monitoring any regulation changes from...

GPCR News

Dec 1, 20211 min read

GPCR Papers

Targeted Therapies to Reduce Side Effects in Modern Drug Development

December 2021 "Drug development is rarely trivial. In fact, it is often costly, frustrating, and tortuous—and more often than not it...

GPCR News

Dec 1, 20211 min read

GPCR Papers

GPCR Signaling and mTORC1 Regulation

The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and...

GPCR News

Dec 1, 20212 min read

GPCR Papers

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal stem cells in multiple...

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