GPCR News 

Location bias contributes to functionally selective responses of biased CXCR3 agonists

Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors

Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...

Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures

Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...

Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...

Structural view of G protein-coupled receptor signaling in the retinal rod outer segment

Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...

Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..

Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy

Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals

Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Endosomal parathyroid hormone receptor signaling

Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases

Allosteric modulation of GPCRs: From structural insights to in silico drug discovery

Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...

Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...