Blog: Blog2

GPCR News

Sep 30, 20221 min read

Allosteric modulation of GPCRs: From structural insights to in silico drug discovery

October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of the prime targets for marketed...

Sep 30, 20221 min read

The complicated lives of GPCRs in cardiac fibroblasts

October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes...

Sep 30, 20221 min read

Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...

October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of G-protein-coupled receptors...

Aug 31, 20221 min read

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...

Aug 31, 20221 min read

GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer

September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and...

Dec 1, 20211 min read

Disentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine

G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins....

Dec 1, 20211 min read

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and ...

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their G protein-coupled receptors in the...