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The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Dr. Kiyan Afzali ‘What we observe is not nature itself, but nature exposed to our method of questioning.’ –Werner Heisenberg 1....
Kiyan Afzali
Mar 1011 min read
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Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of the prime targets for marketed...
GPCR News
Oct 1, 20221 min read
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The complicated lives of GPCRs in cardiac fibroblasts
October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes...
GPCR News
Oct 1, 20221 min read
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Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of G-protein-coupled receptors...
GPCR News
Oct 1, 20221 min read
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Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...
GPCR News
Sep 1, 20221 min read
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GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and...
GPCR News
Sep 1, 20221 min read
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Disentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins....
GPCR News
Dec 1, 20211 min read
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Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and ...
Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their G protein-coupled receptors in the...
GPCR News
Dec 1, 20211 min read
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