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Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
November 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis...
GPCR News
Nov 1, 20221 min read
22 views
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Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding...
GPCR News
Nov 1, 20221 min read
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Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
November 2022 "Despite the growing number of G protein-coupled receptor (GPCR) structures, only 39 structures have been cocrystallized...
GPCR News
Nov 1, 20221 min read
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Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
November 2022 "Dimerization of beta 2-adrenergic receptor (β2-AR) has been observed across various physiologies. However, the function of...
GPCR News
Nov 1, 20221 min read
62 views
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Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
October 2022 Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for...
GPCR News
Oct 1, 20221 min read
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Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various...
GPCR News
Oct 1, 20221 min read
8 views
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GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
October 2022 GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor...
GPCR News
Oct 1, 20221 min read
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Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of Cannabinoid CB1 Receptor...
GPCR News
Oct 1, 20221 min read
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Structure Therapeutics Extends Financing, Advances Diabetes and Obesity Clinical Program and...
August 2022 Structure Therapeutics Extends Financing, Advances Diabetes and Obesity Clinical Program and Changes Name from ShouTi "San...
GPCR News
Aug 1, 20221 min read
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Jan Steyaert Named 2022 Jacob and Louise Gabbay Award Winner
August 2022 "August 12, 2022.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut...
GPCR News
Aug 1, 20221 min read
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Amgen to Acquire Chemocentryx for $4 Billion in Cash
August 2022 "THOUSAND OAKS, Calif. and SAN CARLOS, Calif., Aug. 4, 2022 /PRNewswire/ -- Amgen (NASDAQ: AMGN) and ChemoCentryx, Inc.,...
GPCR News
Aug 1, 20221 min read
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Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
August 2022 Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for Substance Use Disorders "Geneva,...
GPCR News
Aug 1, 20221 min read
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Addex Reports 2022 Half Year and Second Quarter Financial Results and Provides Corporate Update
August 2022 "Geneva, Switzerland, August 18, 2022 - Addex Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company...
GPCR News
Aug 1, 20221 min read
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Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares
August 2022 "August 10, 2022 Cancer Research UK is working with global biopharma Sosei Heptares on a treatment they hope will bring...
GPCR News
Aug 1, 20221 min read
7 views
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Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
August 2022 Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in Schizophrenia "BOSTON--(BUSINESS...
GPCR News
Aug 1, 20221 min read
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SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
August 2022 "We are proud to announce that SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
GPCR News
Aug 1, 20221 min read
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Trevena Reports Second Quarter 2022 Results and Provides Business Update
August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the...
GPCR News
Aug 1, 20221 min read
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G.CLIPS biotech is 2 years old this month!
July 2022 "G.CLIPS biotech is 2 years old today🎂. When I came this morning to work this is how I found my desk. So very grateful to the...
GPCR News
Jul 1, 20221 min read
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Exscientia is 10 years old this July!
July 2022 "Today we are celebrating ten years of Exscientia! Founded as a spinout from the University of Dundee on 20 July 2012,...
GPCR News
Jul 1, 20221 min read
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X4 slashes pipeline, lays off staff just three weeks after netting a $55M PIPE
July 2022 "Not even a PIPE financing could save X4 Pharmaceuticals from enacting layoffs and trimming its pipeline. The Boston biotech...
GPCR News
Jul 1, 20221 min read
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