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The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Dr. Kiyan Afzali ‘What we observe is not nature itself, but nature exposed to our method of questioning.’ –Werner Heisenberg 1....
Kiyan Afzali
Mar 1011 min read
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Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
October 2022 "Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling...
GPCR News
Oct 1, 20221 min read
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Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in honeybee Apis mellifera: An...
GPCR News
Oct 1, 20221 min read
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GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin...
August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors "Serotonin (or...
GPCR News
Aug 1, 20221 min read
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Fusion protein strategies for cryo-EM study of G protein-coupled receptors
August 2022 "Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G...
GPCR News
Aug 1, 20221 min read
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Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies
August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric...
GPCR News
Aug 1, 20221 min read
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Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states....
GPCR News
Aug 1, 20221 min read
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Helix 8 in chemotactic receptors of the complement system
August 2022 "Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a...
GPCR News
Aug 1, 20221 min read
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Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through...
GPCR News
Aug 1, 20221 min read
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Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular...
GPCR News
Aug 1, 20221 min read
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