Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!

Hey there, GPCR Enthusiasts!

Ready for your GPCR quest, so bold and bright?

Join us now, and let's explore with all our might! 🎇

This Week’s Highlights:

Congrats to:

• Remi Janicot, and Mikel Garcia-Marcos for their excellent work on Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors

  
  

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• Learn how to therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) vast repertoire of ways to control cell function.

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GPCR Event Spotlight

11th Adhesion GPCR Workshop  

📍 Mexico City

📅 October 23 - 25, 2024

Get ready to party with GPCRs next week! 🎉

We are bouncing off the walls with excitement to meet you all and geek out about GPCRs. If you haven't signed up, hurry up before the GPCR train leaves the station!

Get ready to be blown away by our fantastic lineup of speakers HERE!

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Classified GPCR News

 Let’s dive into the Classified GPCR News from October 7th to 13th, 2024

Industry News

• Antiverse Raises £3.5M ($4.6M) to Advance Generative AI Antibody Design Platform

• GPCR Safety Panels Launched

• Crinetics Pharmaceuticals Announces October 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

• Neurocrine Biosciences Announces Conference Call and Webcast of Third Quarter 2024 Financial Results

• Novel full MC4 receptor-specific nanobody described

  
  
  
  

Call for GPCR Papers

• Deadline: Nov 1, 2024. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology

GPCR Events, Meetings, and Webinars

• October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference

• November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• HIGHLIGHT Senior Scientist, GPCR Pharmacology

• Research Associate - Professor Graeme Milligan

• Postdoc in Molecular Pharmacology - The Hauser Group

• Postdoctoral Scholar – iPSC in cardiac and endothelial cell function

• Protein Biochemist/Structural Biologist

• Senior Scientist/Staff Scientist, Computational Chemistry

• Postdoc in GPCR mechanosensing 

• Postdoctoral Position

  
  

GPCR Activation and Signaling

• Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells

• Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

• A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1

• GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway
  

GPCR Binders, Drugs, and more

• Global analysis of neuropeptide receptor conservation across phylum Nematoda

• Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions
  

GPCRs in Cardiology, Endocrinology, and Taste

• Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract

• Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes

GPCRs in Neuroscience

• Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats

• Neuropeptide and serotonin co-transmission sets the activity pattern in the C. elegans egg-laying circuit
  

Methods & Updates in GPCR Research

• High-throughput G protein-coupled receptor-based autocrine screening for secondary metabolite production in yeast

• Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors

Structural and Molecular Insights into GPCR Function

• Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition

• Structural basis of psychedelic LSD recognition at dopamine D1 receptor

• Structural basis of μ-opioid receptor targeting by a nanobody antagonist

• Probing the energy landscape of the lipid interactions of the serotonin1A receptor

• Potential allosteric pockets identification of glucagon receptor based on molecular dynamics simulations

• Leukotriene B4 receptor 1 (BLT1) activation by leukotriene B4 (LTB4) and E resolvins (RvE1 and RvE2)

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