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📰 GPCR Weekly News, July 22 to 28, 2024

In the fast-paced world of pharmaceuticals and drug discovery, it is crucial for professionals to stay informed about the latest advancements and breakthroughs. We have 18 GPCR papers, four industry news articles, and two job ads.

This week's highlight includes congrats to:

• Clementine E Philibert and Mikel Garcia-Marcos for their work on Smooth operator(s): dialing up and down neurotransmitter responses by G-protein regulators
  

• András D Tóth, Gábor Turu, and László Hunyady for their research on Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors
  

• Antonios Drakopoulos, Peter Gmeiner, Davide Calebiro, Michael Decker, et al. for their study on Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors

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Dr. GPCR University

Early-Bird Registration Now Open for Premium Members!

We’re thrilled to announce our upcoming courses with Dr. Terry Kenakin! Get your premium membership and enjoy a 25% exclusive discount (1 month FREE trial!). Don’t miss out—secure your spot today!

Courses Schedule and Benefits

• Every Thursday at 10 am EST

• Online Lectures

• 1:1 meeting with Dr. Terry Kenakin

• Reading Materials

• Access to the private group

• Certificate

Explore:

• Key metrics for assessing ligand pharmacology (affinity, efficacy, co-operativity)

• Mechanisms of action for new GPCR ligands

• Essentials for effective GPCR discovery
  

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Discover:

• Advanced cellular assays for GPCR ligand behavior

• Real-time kinetics for predicting activity

• Unique drug profiles from new ligands and GPCR behaviors

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GPCR Event Highlight

Join us in vibrant Mexico City from October 23-25, 2024, for the 11th Adhesion GPCR Workshop! Connect with fellow scientists and dive into the latest in adhesion GPCR biology.

Logo Contest: Submit your design by August 15, 2024, to have your artwork featured at the event.

Sponsorship Opportunities: Boost your brand’s visibility at this scientific event. Contact us at Hello@DrGPCR.com to learn more.

We look forward to your participation!

Register for the AGPCR24 Workshop HERE

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Let’s dive into the Classified GPCR News from July 22 to 28, 2024

GPCR Activation and Signaling

• Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog

• Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-dependent Gene Expression

• Ligand bias at the muscarinic acetylcholine receptor family: opportunities and challenges

• Modulating Vertebrate Physiology by Genomic Fine-Tuning of GPCR Functions

• Smooth operator(s): dialing up and down neurotransmitter responses by G-protein regulators

• Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors

• Inverse Regulation of C-C Chemokine Receptor 3 Oligomerization by Downstream Proteins Indicates Biased Signal Transduction Pathways

• Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression

GPCR Binders, Drugs, and more

• Advances in GPCR-targeted drug development in dermatology

• Advances in small-molecule insulin secretagogues for diabetes treatment

GPCRs in Neuroscience

• Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling

GPCRs in Oncology and Immunology

• Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation

• Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions

• GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

Methods & Updates in GPCR Research

• Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors

Structural and Molecular Insights into GPCR Function

• Vibrational Energy Landscapes and Energy Flow in GPCRs

• Allosterism in the adenosine A2A and cannabinoid CB2 heteromer

• Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells

Industry News

• Confo Therapeutics Announces EUR 60M Series B Financing to Advance a Pipeline of Novel GPCR-Modulating Therapies into Clinical Development

• How To Discover Biologics For Challenging Targets

• Drug discovery, a biophysics perspective

• Bio-Rad Adds Rapid Bispecific Antibody Prototyping and Screening Services to Pioneer Antibody Discovery Platform

GPCR Events, Meetings, and Webinars

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• NEW Postdoctoral Position

• NEW Postdoctoral research position

• Senior or Lead Researcher 

• Senior Scientist, Cryo-Electron Microscopy 

• Postdoctoral Research Associate

• Senior Scientist - Discovery Biotherapeutics  

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