Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024

Get ready for an expedition, GPCR explorers!

Embark on another exciting exploration of the unknown realms of GPCR research. Welcome back to your weekly GPCR quest!

This Week’s Highlights:

Congrats to:

• John Teye Azietaku, our great contributor, for his article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling
  

• Sonja Peter, Brian Bender, Chris De Graaf for their excellent work on Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential

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Today, we started the Principles of Pharmacology II course!

Thank you to all participants in Dr. Terry Kenakin's educational initiative this fall! Your dedication has greatly enriched the learning experience. Let’s keep fostering a collaborative environment for sharing ideas and expanding knowledge!

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We had a blast at the 11th Adhesion GPCR Workshop 2024!

The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers, and enthusiasts worldwide to explore Adhesion GPCRs. The presentations and discussions sparked new ideas and collaborations, shaping the future of the field. We thank all participants for their inspiring contributions and passion.

Classified GPCR News

 Let’s dive into the Classified GPCR News from October 21st to 27th, 2024

Industry News

• UNC School of Medicine to Receive $3-Million Award from ARPA-H’s Sprint for Women’s Health

• Nxera Pharma Wins Biotech Company of the Year and Financing Deal of the Year at the Citeline Japan Awards 2024

• GPCR therapies: Eight promising biotechs hacking the cell signaling pathway

• From Structure to Solution: How Structural Biology Informs the Development of Drugs Targeting G Protein-Coupled Receptors

• Olfactive Biosolutions Establishes Scientific Advisory Board

• GLP-1s like Ozempic are among the most important drug breakthroughs ever

• Goldman-backed drug developer Septerna raises $288 mln in US IPO

  
  

Call for GPCR Papers

• Deadline: Nov 1, 2024. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology

GPCR Events, Meetings, and Webinars

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference

• November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• Scientist I Cell Biology - Tectonic Therapeutic

• PhD fellowship in GPCR mechanosensing

• Senior Scientist, GPCR Pharmacology

• Research Associate - Professor Graeme Milligan

• Postdoc in Molecular Pharmacology - The Hauser Group

• Postdoctoral Scholar – iPSC in cardiac and endothelial cell function

• Protein Biochemist/Structural Biologist

• Senior Scientist/Staff Scientist, Computational Chemistry

  
  

GPCR Activation and Signaling

• A gain of function variant in RGS18 candidate for a familial mild bleeding syndrome

• Fusarium graminearum Ste2 and Ste3 Receptors Undergo Peroxidase-Induced Heterodimerization when Expressed Heterologously in Saccharomyces cerevisiae

• The beta 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors

GPCRs in Neuroscience

• Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice

• Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches

• Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells Derived from Patients Diagnosed with Schizophrenia

• Sphingosine 1-phosphate receptor subtype 1 (S1P1) activity in the course of Alzheimer's disease

GPCRs in Oncology and Immunology

• Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides)

• The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells

Methods & Updates in GPCR Research

• Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene

Reviews, GPCRs, and more

• Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41

Structural and Molecular Insights into GPCR Function

• Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential

• Molecular Dynamics (MD) Simulations Provide Insights into the Activation Mechanisms of 5-HT2A Receptors

• Investigating the Effect of GLU283 Protonation State on the Conformational Heterogeneity of CCR5 by Molecular Dynamics Simulations

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