Enhancing GPCR Research Outreach | Dr GPCR University early-bird registration ends soon!

Hey there, readers!

Take a look at our GPCR coverage for this week. We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.

This week's highlight includes congrats to:

• Miles Thompson, Alexander Hauser, Caroline Gorvin, et al. for their work on GPCR gene variants and human genetic disease

• Ilana Kotliar, Thomas Sakmar, et al. for their study on Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins

• Nicholas Kapolka, Geoffrey Taghon, and Daniel Isom for their research on Advances in yeast synthetic biology for human GPCR biology and pharmacology

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Dr. GPCR University

Early-Bird Registration Open for Premium Members!

Unlock a 25% exclusive discount on these courses with Dr. Terry Kenakin with our premium membership and enjoy a 1-month FREE trial! Don’t miss out—secure your spot today! Registrations for the public will be on Monday! Hurry!

Courses Schedule and Benefits

• Every Thursday at 10 am EST

• Online Lectures

• 1:1 meeting with Dr. Terry Kenakin

• Reading Materials

• Access to the private group

• Certificate of participation

Learn the essentials:

• Measuring the pharmacologic activity of ligands (affinity, efficacy, co-operativity)

• Determining mechanisms of action for new GPCR ligands

• Elements of a comprehensive and effective GPCR discovery

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Master advanced applications:

• Using new cellular assays to analyze GPCR ligand behavior

• Predicting activity and in vivo target coverage with real-time kinetics

• Discovering new ligands and GPCR behaviors for unique drug profiles

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 GPCR Event Highlight

11th Adhesion GPCR Workshop

Join us in vibrant Mexico City from October 23-25, 2024, to connect with fellow scientists and explore the latest in adhesion GPCR biology.

Logo Contest: Let your creativity shine by submitting your design for the Logo Contest before August 15, 2024

Sponsorship Opportunities: Elevate your brand's presence at this scientific event. Contact us at Hello@DrGPCR.com to learn more.

Your participation is eagerly awaited!

Register for the Adhesion GPCR Workshop 2024 HERE

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 Let’s dive into the Classified GPCR News from July 29th to August 4th, 2024

GPCR Activation and Signaling

• ONE-GO: Direct detection of context-dependent GPCR activity

• Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins

• Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle

GPCR Binders, Drugs, and more

• Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators

GPCRs in Oncology and Immunology

• G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression

Methods & Updates in GPCR Research

• GPCR Signaling: A Study of the Interplay Between Structure, Energy, and Function

• Engineering a GPCR-based yeast biosensor for a highly sensitive melatonin detection from fermented beverages

• The calcium-binding photoprotein clytin II: Expression of the preferred human codon-optimized clytin II gene in Chinese hamster ovary-K1 cells and its use in the G-protein-coupled receptor assays

• Predicting the Hallucinogenic Potential of Molecules Using Artificial Intelligence

Reviews, GPCRs, and more

• G protein-coupled receptor (GPCR) gene variants and human genetic disease

• Advances in yeast synthetic biology for human G protein-coupled receptor biology and pharmacology

Industry News

• Muscarinic drugs breathe new life into schizophrenia pipeline

• GPCR Dynamics Reveal Mechanisms for Drug Discovery

• DMS: Linking Protein Structure To Function

• AbbVie Completes Acquisition of Cerevel Therapeutics

• Nxera Pharma attended the Drug Discovery Ecosystem Summit

• Tectonic Therapeutic Announces Closing of Merger with AVROBIO as well as Concurrent Private Placement of $130.7 Million

• Tectonic Therapeutic Announces US IND Clearance for Lead Program, TX45 

GPCR Events, Meetings, and Webinars

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• NEW October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• NEW Postdoc in GPCR mechanosensing 

• Postdoctoral Position

• Postdoctoral research position

• Senior or Lead Researcher 

• Senior Scientist, Cryo-Electron Microscopy 

• Postdoctoral Research Associate

Join Dr. GPCR Ecosystem