Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024

Get your space suits on, GPCR cadets!

The GPCR rocket is all fueled and ready to blast off into a galaxy of incredible advancements, now powered up with a series of cosmic GPCR events for the year ahead. It’s time to mark your calendars and save the dates—let’s make some stellar memories together! 🚀✨

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This Week’s Highlights:

Congrats to:

• Ya-Tzu Li, our notable contributor, for her superb undergrad paper along with Hao-Jen Hsu, Chun-Chun Chang, et al. about State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses

• Joseph Crecelius, Adriano Marchese, et al. for their excellent work on Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5)
  

• Panjamaporn Sangwung, Alejandra Tomas, Kyle Sloop, et al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease
  

• Milena Malcharek, Graham Ladds, et al. for their extensive research on The role of receptor activity-modifying proteins in obesity and diabetes mellitus
  

• Maleesha Ubhayarathna, Christopher Langmead, Gregory Stewart, et al. for their fantastic review on Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders
  

• Leigh Walker, Christopher Langmead, Andrew Lawrence, et al. for their remarkable analysis on Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development

  
  

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Big Update! From 2025, only Premium Members will have access to Classified GPCR News. This transition will enable us to invest in higher-quality content and resources, ensuring our community gets the very best insights and updates!

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Classified GPCR News

 Let’s dive into the Classified GPCR News from October 28th to November 3rd, 2024

Industry News

• Nxera Pharma Operational Highlights and Consolidated Results for the Third Quarter and First Nine Months of 2024

• Nasdaq debutante Septerna swells its IPO to $331m

• Nxera Pharma and Antiverse Enter Collaboration To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative AI

• Zombie Fungi Hijack Hosts’ Brains

• GPCR Therapeutics, Inc. has received Orphan Drug Designation (ODD) from the FDA for its hematopoietic stem cell mobilization agent

• It’s not just obesity. Drugs like Ozempic will change the world

  
  

GPCR Events, Meetings, and Webinars

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• NEW November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat

• November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference

• November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe

• NEW December 10 - 12, 2024 | Pharmacology 2024

• NEW January 13 - 16, 2025 | PepTalk 2025

• NEW January 25 - 29, 2025 | SLAS 2025

• NEW February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery

• NEW February 15 - 19, 2025 | BPS 2025

• NEW February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery

• NEW March 12 - 14, 2025 | NextGen Biomed 2025

• NEW March 25 - 28, 2025 | 10th German Pharm-Tox Summit

• NEW April 1 - 5, 2025 | XXIII GEM Meeting in 2025

• NEW April 3 - 6, 2025 | ASPET 2025

• NEW April 14 - 17, 2025 | 20th Drug Discovery Chemistry

• NEW April 24 - 27, 2025 | American Physiology Summit 2025

• NEW April 25 - 30, 2025 | AACR Annual Meeting 2025

• NEW May 12 - 15, 2025 | PEGS 2025

• NEW May 20 - 22, 2025 | SLAS Europe 2025

• NEW June 16 - 19, 2025 | BIO International Convention 2025

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• Scientist I Cell Biology - Tectonic Therapeutic

• PhD fellowship in GPCR mechanosensing

• Senior Scientist, GPCR Pharmacology

• Research Associate - Professor Graeme Milligan

• Postdoc in Molecular Pharmacology - The Hauser Group

• Postdoctoral Scholar – iPSC in cardiac and endothelial cell function

• Protein Biochemist/Structural Biologist

• Senior Scientist/Staff Scientist, Computational Chemistry

  
  

GPCR Activation and Signaling

• GPCR signalling: Yet another variant route in a highly complex road map

• Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors

• Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5)

• State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses

GPCRs in Cardiology, Endocrinology, and Taste

• Adipose tissue in older individuals: a contributing factor to sarcopenia

• Asprosin regulates male reproduction in teleosts: an in vitro study in Channa punctata

GPCRs in Neuroscience

• Neuron specific quantitation of Gαolf expression and signaling in murine brain tissue

• Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse

GPCRs in Oncology and Immunology

• The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils

• Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking

• The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor

Reviews, GPCRs, and more

• Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors

• Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

• Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease

• The role of receptor activity-modifying proteins in obesity and diabetes mellitus

• Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders

• Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development

• Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases

Structural and Molecular Insights into GPCR Function

• Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination

• Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics

• Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors

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