Exploring the Breakthroughs in GPCR Research

📰 GPCR Weekly News, July 8 to 14, 2024

Hello readers! Check out our GPCR coverage for this week. We have 15 GPCR papers, three industry news, and two job ads.

This week's highlight includes congrats to:

• Remi Janicot, and Dr. Mikel Garcia-Marcos for their work on Get ready to sharpen your tools:A short guide to heterotrimeric G protein activity biosensors
  

• Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research on the Relevance of GPCR dynamics for receptor activation, signalling bias and allosteric modulation
  

• Drs. Badr Sokrat, Michel Bouvier, et al. for their study on the Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes

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Dr. GPCR University

We are excited to announce the dates for our upcoming courses led by Dr. Terry Kenakin. Early-bird registration for premium Ecosystem members opens on July 31st, so mark your calendars and take advantage of the discount!

Course Schedule and Details Every Thursday at 10 am EST

1. Principles of Pharmacology in Drug Discovery I - Techniques for Effective Lead Optimization of Candidate Molecules Dates: September 5th to 26th, 2024 Overview: This course delves into the essential pharmacologic techniques and knowledge necessary to create a GPCR Target Program aimed at discovering new drugs. GPCRs remain one of the most prolific and fertile therapeutic drug targets.

1. Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate Selection Dates: October 3rd to 31st, 2024 Overview: Building on the basics covered in Course I, this course explores advanced methods in GPCR utilization for drug therapy. Topics include the complex pleiotropic behaviors of GPCRs and how these can be harnessed for innovative drug discovery.

GPCR Event Highlight

11th Adhesion GPCR Workshop Hosted by the Adhesion GPCR Consortium, this event will be held in vibrant Mexico City from October 23 to 25, 2024. Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology.

Important Deadlines:

• Abstract Submission: July 22, 2024. Submit your abstract today; the deadline is fast approaching!

• Logo Contest: Unleash your creativity and submit your design by August 15, 2024.

Sponsorship Opportunities: Explore options for sponsoring this prestigious event. For more information, contact us at Hello@DrGPCR.com.

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Let’s dive into the Classified GPCR News from July 8th to 14th, 2024

GPCR Activation and Signaling

• GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress

• Two C-terminal isoforms of Aplysia tachykinin-related peptide receptors exhibit phosphorylation-dependent and independent desensitization mechanisms

• Get ready to sharpen your tools:A short guide to heterotrimeric G protein activity biosensors

• Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach

• Mechanisms controlling haemolymph circulation under resting conditions in the chagas disease vector Rhodnius Prolixus (Stål)

• Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes

GPCRs in Neuroscience

• An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake

• The tick Ixodes scapularis has five different GPCRs specifically activated by ACP (adipokinetic hormone/corazonin-related peptide)

GPCRs in Oncology and Immunology

• S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia

Methods & Updates in GPCR Research

• High-throughput G protein-coupled receptor-based autocrine screening for secondary metabolite production in yeast

Reviews, GPCRs, and more

• Class B1 GPCRs: Insights into Multi-Receptor Pharmacology for the Treatment of Metabolic Disease

• Relevance of G protein-coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

Structural and Molecular Insights into GPCR Function

• Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor

• Influence of the Water Model on the Structure and Interactions of the GPR40 Protein with the Lipid Membrane and the Solvent: Rigid versus Flexible Water Models

• Probing the energy landscape of the lipid interactions of the serotonin1A receptor

Industry News

• Neurocrine Biosciences Announces Conference Call and Webcast of Second Quarter 2024 Financial Results

• G-Protein Coupled Receptors Global Market 2024 To Reach $4.09 Billion By 2028 At Rate Of 6.5%

• Trevena Announces $2M Non-Dilutive Financing Tranche and Reduction in Outstanding Liabilities in Connection with Existing ex-US Royalty Financing

• EuroscreenFast and GW Vitek Announce Strategic Distribution Partnership in Korea 

GPCR Events, Meetings, and Webinars

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Postdoctoral Research Associate

•  Senior Scientist - Discovery Biotherapeutics

• Post-Doctoral Fellow/Trainee

• Scientist; Biochemistry, Cellular and Mechanistic Pharmacology; Lead Discovery and Optimization 

• Director/Sr. Director GPCR Drug Discovery Biologist 

• Post-Doctoral Scientist- Molecular Pharmacology (FDE)

Join Dr. GPCR Ecosystem