📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!

Dear GPCR Enthusiasts!

Get ready to save the dates! Dr. GPCR University offers two live courses this fall that you won’t want to miss.

Before the new semester kicks off, dive into our premium on-demand courses! With your membership, you’ll access over 500 minutes of top-notch content from Drs. Kenakin and Hoare on ' Applying Pharmacology to Drug Discovery' and 'Advanced Data Analysis for GPCR Pharmacology.'

Choose between our monthly or yearly plans (with a 5-day free trial) to enjoy these courses and snag 25% off early bird discounts on upcoming classes.

Check out what’s coming in September and October:

Sign up for both courses now and score a 25% early bird discount with a premium membership!

Course Details:

• When: Thursdays at 10 AM EST

• Format: Engaging Online Lectures with access to pre-read materials.

Perks Include:

• In-depth Reading Materials

• Access to a Private Community

• Certificate of Participation for each course

Don’t miss out—grab this special offer today!s

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Check out the details of each course below:

Open to the Public: Enrollment is Now Available!

Hurry and secure your spot TODAY!

Dates: September 5 to 26, 2024

What You’ll Learn during the four sessions:

• How to measure pharmacologic activity of ligands (affinity, efficacy, co-operativity)

• Determining mechanisms of action for new GPCR ligands

• Key elements of a comprehensive and effective GPCR discovery strategy

  
  

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Exclusive 25% Early Bird Discount for Dr. GPCR Ecosysme Premium members. Secure your spot before public enrollment opens!

Dates: October 3 to 31, 2024

What You’ll Master during the five sessions:

• Utilizing new cellular assays to analyze GPCR ligand behavior

• Predicting activity and in vivo target coverage with real-time kinetics

• Discovering new ligands and unique GPCR behaviors for innovative drug profiles

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GPCR Event Highlight

 11th Adhesion GPCR Workshop  

Location: Mexico City

Dates: October 23-25, 2024

Join us in the vibrant heart of Mexico City to connect with fellow scientists and delve into the latest advances in adhesion GPCR biology.

Logo Contest: Let your creativity shine! Submit your design for our Logo Contest by August 15, 2024 (Yes, it's TODAY)!

Sponsorship Opportunities: Elevate your brand’s visibility at this prestigious event. Contact us at Hello@DrGPCR.com to explore sponsorship options.

Your participation is eagerly awaited!

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This week's highlight includes congrats to:

Miles Thompson, Alexander Hauser, Caroline Gorvin, et al. for their work on GPCR pharmacogenomics

 Let’s dive into the Classified GPCR News from August 5th to 11th, 2024

GPCR Activation and Signaling

• Pharmacological characterization of the zebrafish Hrh2a histamine H2 receptor

• Revealing the graded activation mechanism of neurotensin receptor 1

• Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP

• Olanzapine manipulates neuroactive signals and may onset metabolic disturbances

GPCR Binders, Drugs, and more

• Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors

GPCRs in Neuroscience

• In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling

• Striatal serotonin release signals reward value

• Ciliary length variations impact cilia-mediated signaling and biological responses

• The receptor tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease

• Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans

• Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons

Methods & Updates in GPCR Research

• G protein-coupled receptor (GPCR) pharmacogenomics

• Visualization of endogenous G proteins on endosomes and other organelles

Reviews, GPCRs, and more

• Phytocannabinoids in neuromodulation: From omics to epigenetics

• The impact of nanobodies on GPCR structural biology and their potential as therapeutic agents

Industry News

• Nxera Pharma Operational Highlights and Consolidated Results for the Second Quarter and First Half 2024

• Cracking Codes in Cellular Communication

• Neurocrine Biosciences to Present at the Canaccord Genuity 44th Annual Growth Conference

• GPCR drugs make up a third of the market! GPCRs and mRNA antigens enable drug discovery and development

• Mapping GPCR-RAMP complexes with MolBoolean

• Screening GPR75 Modulators Using Medium-Throughput Reporter Gene Assay

• GPCR Therapeutics Optimizes the Joint Development of New Drugs Using Intralinks’ Virtual Data Room 

GPCR Events, Meetings, and Webinars

• NEW September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• Postdoc in GPCR mechanosensing 

• Postdoctoral Position

• Postdoctoral research position

• Senior or Lead Researcher 

• Senior Scientist, Cryo-Electron Microscopy 

• Postdoctoral Research Associate

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