GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024

Hello GPCR Community,

Stay up-to-date with the latest GPCR research, including breakthrough studies, upcoming events, and our newly announced pharmacology courses. Don't miss exclusive discounts, expert insights, and opportunities to elevate your learning with our tailored programs. Secure your spot today and dive into the evolving world of GPCRs!

This week's highlights include congrats to:

• Bruce Allen, Terence Hébert, et al. for their work on Understanding the impact of nuclear-localized GPCRs on cellular signaling.
  

• Lukas Grätz, Jan Voss, and Gunnar Schulte, for their study on Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs.
  

• Małgorzata Kogut-Günthel, Antonella Di Pizio, et al. for their research on The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.

  
  

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🎉 New Course Dates Announced: Don’t Miss Out!

Our refreshed schedule is designed to fit seamlessly into your calendar and enhance your learning experience. Every Thursday at 10 AM EST:

• Principles of Pharmacology I

  • October 3, 10, 17, 24 (four sessions)

  • Explore pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies.
    

• Principles of Pharmacology II

  • October 31, November 7, 14, 21, December 5 (five sessions) (we skipped Thanksgiving, of course!)

  • Delve into new cellular assays, real-time kinetics, and unique GPCR behaviors.

🔥 Why You Should Enroll Now:

• Act Fast & Save Big! The Principles of Pharmacology I & II BUNDLE is your golden ticket to mastering the field. Premium members can enjoy a 25% OFF early bird discount, but hurry - it's only available for a limited time. Not a premium member yet? Don't worry - we offer a 5-day FREE trial! Plus, access to over 500 minutes of recorded classes of our GPCR Courses with Drs. Terry Kenakin and Sam Hoare!
  

• Affordable & Unique Learning Experience Dive deep into pharmacology with our budget-friendly courses that offer a unique approach to understanding the field.
  

• Rewatch Anytime Enjoy the flexibility of rewatching sessions at your convenience to reinforce your learning.

Save Your Spot Today!

Don't miss out on our fantastic discussion with Dr. Terry Kenakin on what to anticipate for these courses!

Special Offer for Scientists who work and live in developing countries

If you live and work in a developing country, please fill out this form to receive complimentary access to Dr. Kenakin's upcoming classes. We’re committed to making education accessible to all!

Secure your spot today and elevate your pharmacology expertise! Don’t miss this chance to benefit from our early bird pricing and premium content.

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GPCR Event Spotlight

Discovery on Target’s 19th Annual GPCR-Based Drug Discovery

Targeting G Protein-Coupled Receptors for New Therapeutic Options

📍 Boston, MA

📅 October 2 -3, 2024

GPCRs, among the most ancient and complex drug targets, remain central in modern targeted drug discovery. The 19th Annual GPCR-Based Drug Discovery conference (October 2-3, 2024, in Boston and online) gathers top researchers to explore the latest advances in designing precise GPCR-targeted drugs, including the role of machine learning, new biophysical techniques, and medicinal chemistry approaches in understanding these challenging receptors.

Join us October 2-3 at the GPCR Drug Discovery Conference. Register today and save $200 off the current rate. Use discount code “DRGPCR24” to save.

11th Adhesion GPCR Workshop  

📍 Mexico City

📅 October 23-25, 2024

Join us to connect with peers and explore the latest in adhesion GPCR biology. Full Agenda Coming Soon!

Are you interested in boosting your brand? Contact us at Hello@DrGPCR.com for sponsorship opportunities.

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Classified GPCR News

 Let’s dive into the Classified GPCR News from August 26th to September 1st, 2024

Industry News

• GPCR-RAMP Interactome Maps Could Help Drug Developers Find Buried Treasures

• Edelris Announces Research Services Agreement with Pfizer on Targeted Protein Degradation Modalities

• A quick revision of how β-adrenergic receptors work and how their antagonists can achieve therapeutic outcomes.

• Domain Nominated for Prestigious Prix Galien USA ‘Best Startup’ Award: Pioneering GPCR-Driven Immunotherapies in Cancer Treatment

• Structure Therapeutics Appoints Angus C. Russell to Board of Directors

• Adiso Announces Groundbreaking Research Highlighting ADS024 a Novel Oral Agent for Neuroinflammation

Call for GPCR Papers

• Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology

GPCR Events, Meetings, and Webinars

• September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• September 30 - October 3, 2024 | 22nd Discovery on Target

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• HIGHLIGHT Research Associate - Professor Graeme Milligan

• NEW Postdoc in Molecular Pharmacology - The Hauser Group

• NEW Senior Scientist/Staff Scientist, Computational Chemistry

• Postdoc in GPCR mechanosensing 

• Postdoctoral Position

• Postdoctoral research position

• Senior or Lead Researcher 

GPCR Activation and Signaling

• Profiling the proximal proteome of the activated μ-opioid receptor

• Understanding the impact of nuclear-localized GPCRs on cellular signalling

• GRK2 is critical for the cleavage of the porcine embryo by regulating HSP90 and the AKT pathway

• Structural basis for CCR6 modulation by allosteric antagonists

• Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs

GPCRs in Neuroscience

• Opposing GPCR signaling programs protein intake setpoint in Drosophila

• Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in Depression

GPCRs in Oncology and Immunology

• Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma

• Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)

• Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes

Methods & Updates in GPCR Research

• A nondestructive membrane engineering method using an amphiphilic polymer

• Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe

• Selective optogenetic inhibition of Gαq or Gαi signaling by minimal RGS domains disrupts circuit functionality and circuit formation

Reviews, GPCRs, and more

• G Protein-Coupled Receptors in Skin Aging

• The path to the G protein-coupled receptor structural landscape: Major milestones and future directions

• Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer

Structural and Molecular Insights into GPCR Function

• Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

• Altered O-glycosylation of β1-adrenergic receptor N-terminal single-nucleotide variants modulates receptor processing and functional activity

• Differential pathogenetic mechanisms of mutations in helix 2 and helix 6 of rhodopsin

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