📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024

Dear GPCR Community,

Before diving into this week's news, prepare for an incredible learning journey! We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you to join us on these new dates.

Here’s the refreshed schedule:

Principles of Pharmacology I

• October 3, 10, 17, 24

Principles of Pharmacology II

• October 31

• November 7, 14, 21

• December 5

As a premium member, you’re also unlocking over 500 minutes of exclusive, expert-led content from thought leaders like Drs. Kenakin and Hoare. Don’t miss out on insightful resources like ' Applying Pharmacology to Drug Discovery' and 'Advanced Data Analysis for GPCR Pharmacology.'

We’re thrilled to have you with us on this learning journey!

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Courses Highlights

The clock is ticking! Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE. Grab your spot today and score a 25% early bird discount—exclusively for premium members. Register now and level up your expertise! Become a premium member today and enjoy a 5-day free trial.

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• Enrollment: Open to the Public Now!

• Dates: October 3 to 24, 2024 (four sessions)

• Topics: Measuring pharmacologic activity, mechanisms of action, and GPCR discovery strategies.

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• Discount: 25% off for Premium Members—Act Fast!

• Dates: October 31, November 7 - 14 -21, and December 5, 2024 (five sessions)

• Topics: New cellular assays, real-time kinetics, and discovering unique GPCR behaviors.

  
  

Sign up today to secure your spot!

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GPCR Event Spotlight

  11th Adhesion GPCR Workshop  

• Location: Mexico City

• Dates: October 23-25, 2024

• Join us to connect with peers and explore cutting-edge adhesion GPCR biology.

Don't miss the chance to boost your brand's presence at this exclusive event. Contact us at Hello@DrGPCR.com to discover exciting sponsorship opportunities.

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This week's highlight includes congrats to:

• Madison Walker, Benjamin Myers, et al., for their research on GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade
  

• Elita Yuliantie, Arthur Christopoulos, Patrick M. Sexton, Denise Wootten, et al., for their work on Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs

 Let’s dive into the Classified GPCR News from August 12th to 18th, 2024

Adhesion GPCRs

• Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors

GPCR Activation and Signaling

• A-Kinase-Anchoring-Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle

• GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade

• Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai

GPCR Binders, Drugs, and more

• Photo-BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor

• Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs

GPCRs in Cardiology, Endocrinology, and Taste

• Regulator of G-protein signaling expression in human intestinal enteroendocrine cells and potential role in satiety hormone secretion in health and obesity

GPCRs in Neuroscience

• Light and dopamine impact two circadian neurons to promote morning wakefulness

• LPA3 agonist-producing Bacillus velezensis ADS024 is efficacious in multiple neuroinflammatory disease models

• Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties

GPCRs in Oncology and Immunology

• Chemoattractant receptor signaling in humoral immunity

Methods & Updates in GPCR Research

• Probing PAC1 receptor activation across species with an engineered sensor

• A Multi-Angle Approach to Predict Peptide-GPCR Complexes: The N/OFQ-NOP System as a Successful AlphaFold Application Case Study

• Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors in Drosophila

• Measuring G protein activation by spectrally resolved imaging fluorescence fluctuation spectroscopy

Structural and Molecular Insights into GPCR Function

• Monitoring GPCR conformation with GFP-inspired dyes

• Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor

• Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy

• Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy

Industry News

• Crinetics Pharmaceuticals Announces August 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

• Unlocking New Possibilities in GLP-1R Drug Discovery

GPCR Events, Meetings, and Webinars

• September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• Postdoc in GPCR mechanosensing 

• Postdoctoral Position

• Postdoctoral research position

• Senior or Lead Researcher 

• Senior Scientist, Cryo-Electron Microscopy 

• Postdoctoral Research Associate

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