📰 GPCR Weekly News

Hello Readers👋,

Get the latest GPCR News more frequently directly in your inbox and in the Ecosystem. Below is your Classified GPCR News at a glance for December 5 to December 11th, 2022.

GPCR Activation and Signaling

• Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives

• Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets

• Constitutive activity of the dopamine receptor D5R, highly expressed in CA1 hippocampal neurons, selectively reduces CaV 3.2 and CaV 3.3 currents

GPCR Binders, Drugs, and more

• LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice

Methods & Updates in GPCR Research

• Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor

Reviews, GPCRs, and more

• Life, death and resurrection of plant GPCRs

Structural and Molecular Insights into GPCR Function

• Synergistic and Competitive Lipid Interactions in the Serotonin 1A Receptor Microenvironment

Industry News

• Addex and Indivior Extend Research Term Of Substance Use Disorder Gabab Positive Allosteric Modulator Discovery Collaboration

• Domain Therapeutics strengthens Scientific Advisory Board with appointment of immuno-oncology experts

• More millions roll in for Sosei Heptares

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline February 12, 2023.

• Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology.

GPCR Events, Meetings, and Webinars

• 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston.

• ERNEST GPCR early career investigator (ECI) Zoominar Survey

• 2nd ERNEST Training School – February 20th to March 3rd.

• GEM2023 (14-17 March 2023).

• 8th and final ERNEST Meeting May 3-7, 2023 in Crete.

• The Illuminating the Understudied Druggable Proteome Conference. June 4-8,2023.

• 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11.

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. June 11-16, 2023.

• 19th World Congress of Basic & Clinical Pharmacology 2023. July 2 - 7.

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