📰 GPCR Weekly News, April 10 to 16, 2023

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Below is your Classified GPCR News at a glance for April 10 to 16, 2023.

Adhesion GPCRs

• Downstream signaling of the disease associated mutations on GPR56/ADGRG1.

GPCR Activation and Signaling

• Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor.

GPCR Binders, Drugs, and more

• Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.

GPCRs in Cardiology, Endocrinology, and Taste

• G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.

GPCRs in Neuroscience

• GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide.

• Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens.

• Multiple subthreshold GPCR signals combined by the G proteins Gαq and Gαs activate the C. elegans egg-laying muscles.

GPCRs in Oncology and Immunology

• G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis.

Methods & Updates in GPCR Research

• Activity Map and Transition Pathways of G Protein-Coupled Receptor Revealed by Machine Learning.

• Computational insights into ligand-induced G protein and β-arrestin signaling of the dopamine D1 receptor.

• In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies.

Reviews, GPCRs, and more

• Internal and external modulation factors of the orexin system (REVIEW).

Structural and Molecular Insights into GPCR Function

• Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.

• Transmembrane protein CD69 acts as an S1PR1 agonist.

Industry News

• A Current View of Allosteric GPCR Drug Discovery from the 2nd Annual GPCRs-Targeted Drug Discovery Summit, Boston MA

• Pathios Therapeutics Unveils PTT-4256, a Highly Potent and Selective Inhibitor of GPR65, in Presentation at American Association for Cancer Research (AACR) Annual Meeting 2023

• Setting GPCRs free

• Dr. Michel Bouvier received the title of Doctor Honoris Causa from the Université de Montpellier

• Domain Therapeutics presented 3 posters at AACR 2023

• Exscientia presented a poster at AACR 2023

• Pathios Therapeutics presented a poster at AACR 2023

GPCR Events, Meetings, and Webinars

• NEW FREE 7th ERNEST GPCR zoominar (April 20, 2023)

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• Swiss Biotech Day (April 24 - 25, 2023)

• ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Director - Targeted Oncology

• NEW Senior Scientist - Antibody Engineering

• NEW Scientist—Immuno-Oncology

• Convergent Research - Senior Scientist, Cell-Based Assay Development

• Post Doctoral Fellow

• Research associate in protein production

• Vice President, Oncology Clinical Research

• PostDoctoral Associate

• PostDoctoral Position

• Team Lead protein production and profiling

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