📰 GPCR Weekly News, April 17 to 23, 2023

Hi friends!👋 Take a look at the latest and greatest in GPCR research. This week's GPCR papers feature authors such as Drs. Bryan Roth, Sudarshan Rajagopal, and Graeme Milligan.

Save the date! Dr. GPCR Symposium on GPCR Activation and Signaling, May 19th, 2023. Submit your interest in giving a talk or presenting a poster to Hello@DrGPCR.com. Don't miss out! Just 3 weeks away! Stay updated with the latest Dr. GPCR News by subscribing to our monthly newsletter.

Below is your Classified GPCR News at a glance for April 17 to 23, 2023.

GPCR Activation and Signaling

• How can we improve the measurement of receptor signaling bias?

• Phosphorylation barcodes direct biased chemokine signaling at CXCR3.

• The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.

• Subcellular location defines GPCR signal transduction.

• Regulation of the pro-inflammatory G protein-coupled receptor GPR84.

GPCR Binders, Drugs, and more

• Development of a 5-HT7 receptor antibody for the rat: the good, the bad, and the ugly.

GPCRs in Cardiology, Endocrinology, and Taste

• FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome.

GPCRs in Neuroscience

• G protein coupled receptors as targets for transformative neuropsychiatric therapeutics.

GPCRs in Oncology and Immunology

• CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases.

Methods & Updates in GPCR Research

• Solvent accessibility of a GPCR transmembrane domain probed by in-membrane chemical modification (IMCM).

Structural and Molecular Insights into GPCR Function

• Lysophosphatidic acid, a simple phospholipid with myriad functions.

Industry News

• Data Presented at AACR 2023 Highlights Exscientia’s Clinical and Preclinical Development

• The pathway of opioid drugs into cellular structures

• Inversago Pharma will present at BBHIC 2023

• Orion Biotechnology attended the Swiss Biotech Day

• Addex Therapeutics attended the Swiss Biotech Day

• Sosei Heptares presented novel Computational Chemistry and Cheminformatics approaches for GPCR SBDD at UK QSAR Spring Meeting 2023

• What the HEK?

GPCR Events, Meetings, and Webinars

• ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Postdoctoral Researcher

• Director - Targeted Oncology

• Senior Scientist - Antibody Engineering

• Scientist—Immuno-Oncology

• Convergent Research - Senior Scientist, Cell-Based Assay Development

• Post Doctoral Fellow

• Research associate in protein production

• Vice President, Oncology Clinical Research

Explore Dr. GPCR Ecosystem