📰 GPCR Weekly News, April 24 to 30, 2023

Greetings fellow GPCR enthusiasts! This week's GPCR papers feature publications from Drs. Thomas P. Sakmar, Debbie L. Hay, Lukas Grätz, and more. Check out some of the latest GPCR discoveries below!

Before you do so, mark your calendars and join us for the Dr. GPCR Symposium on GPCR Activation and Signaling on May 19th, 2023. If you're presenting a poster, submit your poster using the poster form.

Also, keep yourself updated with the latest Dr. GPCR News by subscribing to our monthly newsletter.

Below is your Classified GPCR News at a glance for April 24 to 30, 2023.

Adhesion GPCRs

• Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic force microscopy.

• Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.

GPCR Activation and Signaling

• The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.

• A visual opsin from jellyfish enables precise temporal control of G protein signalling.

GPCR Binders, Drugs, and more

• Allosteric modulation of a human odorant receptor.

• Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells.

• Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.

• Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells.

GPCRs in Cardiology, Endocrinology, and Taste

• Targeting G Protein-Coupled Receptors for Heart Failure Treatment.

• Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with small molecules.

• Novel roles for G protein-coupled receptor kinases in cardiac injury and repair.

GPCRs in Neuroscience

• Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.

GPCRs in Oncology and Immunology

• Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

• Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts.

• Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.

Methods & Updates in GPCR Research

• NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.

Reviews, GPCRs, and more

• G protein-coupled receptor-targeting antibody-drug conjugates: Current status and future directions.

• Genetic variants of G-protein coupled receptors associated with pubertal disorders.

• RGS proteins and their roles in cancer: friend or foe?.

Structural and Molecular Insights into GPCR Function

• Cryo-EM structure of the endothelin-1-ETB-Gi complex.

• WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.

Industry News

• Orion Biotechnology will be participating in a panel discussion at the LSX World Congress

• Novel living yeast-based dual biosensor for detecting peptide variants

• The Galien Foundation Announces 2023 Prix Galien UK Award Candidates

• Exscientia Appoints Harvard Professor Franziska Michor, Ph.D. to Board of Directors

GPCR Events, Meetings, and Webinars

• ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• NEW PEGS Boston (May 15 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Associate Scientist - Technology

• NEW Senior Research Scientist/Principal Scientist- Technology

• NEW Tissue Culture Scientist/Tissue Culture Manager

• Postdoctoral Researcher

• Director - Targeted Oncology

• Senior Scientist - Antibody Engineering

• Scientist—Immuno-Oncology

• Convergent Research - Senior Scientist, Cell-Based Assay Development

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