📰 GPCR Weekly News, April 3 to 9, 2023

Hello, fellow GPCR enthusiasts! 👋 Check out the latest advancements in GPCR studies.

For Dr. GPCR News, please subscribe to our monthly newsletter. Also, please mark your calendar for the next Dr. GPCR Symposium on GPCR Activation and Signaling held on May 19th, 2023. The program is under construction but if you’d like to give a talk or present a poster, email us at Hello@DrGPCR.com

Below is your Classified GPCR News at a glance for April 3rd to 9th, 2023.

GPCR Activation and Signaling

• Phosphorylation barcodes direct biased chemokine signaling at CXCR3.

• SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression.

• GABABR silencing of nerve terminals.

GPCR Binders, Drugs, and more

• Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands.

• The molecular basis of the antidepressant action of the magic mushroom extract, psilocin.

• Sodium is a negative allosteric regulator of the ghrelin receptor.

GPCRs in Cardiology, Endocrinology, and Taste

• Novel roles for G protein-coupled receptor kinases in cardiac injury and repair.

• DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts.

• βHB inhibits glucose-induced GLP-1 secretion in GLUTag and human jejunal enteroids.

GPCRs in Neuroscience

• G protein-coupled receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders.

• Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.

• GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency.

• GPR37L1 controls maturation and organization of cortical astrocytes during development.

Methods & Updates in GPCR Research

• The Road to Quantitative Lipid Biochemistry in Living Cells.

• Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor.

Reviews, GPCRs, and more

• Heterotrimeric G proteins regulate planarian regeneration and behavior.

• Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.

• β- Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives.

Structural and Molecular Insights into GPCR Function

• Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET.

• Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs.

Industry News

• Orion Biotechnology at the AACR 2023.

• Eurofins Discovery Acquires CALIXAR, Expanding Integrated Drug Discovery Capabilities and Expertise.

• Domain Therapeutics to present three posters at AACR 2023 annual meeting.

GPCR Events, Meetings, and Webinars

• NEW AACR 2023 - American Association for Cancer Research (April 14 - 19, 2023).

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• Swiss Biotech Day (April 24 - 25, 2023)

• NEW ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• Convergent Research - Senior Scientist, Cell-Based Assay Development

• Post Doctoral Fellow

• Research associate in protein production

• Vice President, Oncology Clinical Research

• PostDoctoral Associate

• PostDoctoral Position

• Team Lead protein production and profiling

• Pharmacologist

• Postdoctoral positions at UC San Diego

• Medical Director

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

Explore Dr. GPCR Ecosystem