📰 GPCR Weekly News, August 14 to 20, 2023

Hello readers! Check out the latest advancements in GPCR studies.

This week's highlights:

• Dr. Vladimir Katanaev and colleagues identified compromised GPCR signaling in cancer cells using improved methods for channel capacity estimation.

• Congrats to the GPCR Therapeutics team for their recent paper in the American College of Clinical Pharmacology!

What are you doing September 7-8th? Don't miss the 3rd ECI GPCR 2-day symposium organized by and for early career investigators (ECIs) exploring the fascinating world of GPCRs. Abstract submission for oral presentations closes at 11:30 pm EST today! Abstract submission for poster presentations closes at 11:30 pm EST on August 30, 2023. Registrations close on September 6 at 12pm EST

Mark your calendars for September 22nd! We're hosting the Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Share your project in an informal setting with a 1-minute abstract video using this form. Our poster session is now a discussion on Kumospace.

The GPCR Retreat is coming up November 2-4! We're proud sponsors of this historic event. Submit poster abstracts using this form; short talks will be selected from submissions. Early-bird registration and abstract submissions close on September 8, and final registration ends on September 21. Hurry!

Stay updated with our monthly Dr. GPCR Newsletter!

Remember to check out the weekly Classified GPCR News from August 14 to 20, 2023

Adhesion GPCRs

• Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 ( Adgrf1)

GPCR Activation and Signaling

• Single-molecule analysis reveals that a glucagon-bound extracellular domain of the glucagon receptor is dynamic

• Ligand recognition and G protein coupling of the human itch receptor MRGPRX1

• Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer cells

GPCRs in Neuroscience

• Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens

• Understanding the Molecular Regulation of Serotonin Receptor 5-HTR1B-β-Arrestin1 Complex in Stress and Anxiety Disorders

GPCRs in Oncology and Immunology

• Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

• PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer

• A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

Methods & Updates in GPCR Research

• Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace THC in Sewage

• Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

Structural and Molecular Insights into GPCR Function

• A method for structure determination of GPCRs in various states

• Apelin receptor dimerization and oligomerization

• Molecular Insights into GPCR Mechanisms for Drugs of Abuse

Industry News

• 'GPCR Therapeutics' latest science paper was published by the American College of Clinical Pharmacology

• Sosei and Cancer Research UK announce first patient dosed with oral immunotherapy drug

• Trevena Reports Second Quarter 2023 Results and Provides Business Update

• Crinetics Pharmaceuticals: Paltusotine Phase 3 Data Presented At ENDO

• Novo Nordisk to Acquire Inversago Pharma

GPCR Events, Meetings, and Webinars

• NEW Antiverse: Reimagining Therapeutic Antibodies Using AI

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023)

• 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023)

• Discovery On Target - DOT (September 25 - 28, 2023)

• Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT (September 27 - 28, 2023)

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023)

• MPGPCR Conference (November 15 -17, 2023)

• ASCEPT Annual Scientific Meeting (November 20 -23, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW PhD Student Position

• NEW (Junior) Research Associate Protein Science

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

• Postdoc Research Associate

• Director, Regulatory Affairs

• Research Scientist/Senior Scientist I - Molecular Pharmacology

• Director, Clinical Data Management

• Director, Discovery Toxicology

Explore Dr. GPCR Ecosystem