📰 GPCR Weekly News, December 4 to 10, 2023

Hi GPCR lovers! We have some exciting news, this week we’ve curated 13 GPCR papers, 4 industry news, and 3  job opportunities!

This week's highlight:

• Dr. Bryan L Roth study on Illuminating the understudied GPCR-ome

Save the dates:

• February 8 - 29: Dr. GPCR University live Zoom sessions hosted by Dr. Terry Kenakin. This comprehensive course covers fundamental pharmacology in four weekly segments, delving into Agonists, Antagonists, and Allosteric Modulators.  Registrations open on December 15th and close on February 1st to both Dr. GPCR Ecosystem members and non-members, with limited spots available for 20 attendees at USD 299. The package includes four live Zoom sessions, a one-year Dr. GPCR Ecosystem Premium membership, a personal meeting opportunity with Dr. Kenakin, access to a dedicated group, course materials, recordings, and a completion certificate endorsed by Dr. Kenakin and Dr. GPCR. For more information click HERE, don’t miss out on this exclusive opportunity!

Now check out the weekly Classified GPCR News from December 4th to 10th, 2023.

GPCR Activation and Signaling

• Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers

• Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist

• Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism

GPCR Binders, Drugs, and more

• Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor

GPCRs in Neuroscience

• Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours

• Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in female Schistosoma mansoni

• A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets

• Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder

GPCRs in Oncology and Immunology

• Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice

Methods & Updates in GPCR Research

• Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+ in promoting yolk globule fusion and regulating oocyte maturation

• 19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor

Reviews, GPCRs, and more

• Structure, function and drug discovery of GPCR signaling

• Illuminating the understudied GPCR-ome

Industry News

• Sosei Heptares’ Partner Neurocrine Biosciences Confirms its Plans to Evaluate Two New Muscarinic Agonist Candidates in Phase 1 Clinical Studies 

• AbbVie to acquire neuroscience drugmaker Cerevel Therapeutics for $8.7 billion 

• FDA approves two gene therapies for sickle cell disease, including first that uses CRISPR

• Pier Vincenzo Piazza, CEO of AELIS FARMA, Honored with Merit Medal by Nouvelle-Aquitaine Region Governor  

GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Postdoctoral Fellow

• NEW Post-Doc Research Associate

• NEW Assistant/Associate Professor 

• Principal scientist – oncology biomarker expert

• Postdoctoral Fellow

• Scientific Assistant  

• Scientist

• Lead Researcher

Explore Dr. GPCR Ecosystem