📰 GPCR Weekly News, February 12 to 18, 2024

Greetings, avid readers! We are thrilled to present our comprehensive GPCR coverage for the week; we have 14 GPCR papers, six industry news, and two job ads.

This week's highlight includes congrats to

• Julia Gardner, Dr. Dylan Scott Eiger, Chloe Hicks,  Dr. Sudarshan Rajagopal, et al. for their finding that GPCR kinases affect biased signaling downstream of CXCR3 based on their location.

• Drs. Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric Engagement.

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Dr. GPCR Symposia

Our upcoming symposium on March 15th is about GPCR activation and signaling. Confirmed speakers include Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, and Michel Bouvier. 

We will also have a poster session in breakout rooms on Zoom; if you are interested in sharing your work with our community, kindly fill out this form. Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey.

Dr. GPCR University

The past two weeks of the Dr. GPCR University course, 'Applying Pharmacology to Drug Discovery,' led by Dr. Terry Kenakin, have been amazing. Attendees have actively participated in discussions and asked thought-provoking questions. 

If you missed the chance to register, don't worry! You can still join this waitlist and be the first to know when the live course is offered later this year.

Dr. GPCR Volunteers

Join our dynamic team as a volunteer! You'll share your contributor articles with the community, stay updated with GPCR literature, join a dynamic team, network with GPCR scientists at our events, and get a complimentary Premium Membership with only 4 hours/monthly commitment on your part.

If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com.

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Dr. GPCR Partnered Events

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd GPCRs Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10.

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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Let’s dive into the Classified GPCR News from February 12th to 18th, 2024

GPCR Activation and Signaling

• Fine-tuning activation specificity of G-protein-coupled receptors via automated path searching

• Heterotrimeric G protein signaling without GPCRs: the Gα-binding-and-activating (GBA) motif

• Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor

• GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization

• Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor

• Why classical receptor theory, which ignores allostery, can effectively measure the strength of an allosteric effect as agonist's efficacy

GPCR Binders, Drugs, and more

• Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

• Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist for the atypical chemokine receptor ACKR3

GPCRs in Cardiology, Endocrinology, and Taste

• The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes

GPCRs in Neuroscience

• Voltage tunes mGlu5 receptor function, impacting synaptic transmission

• The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology

• Common changes in rat cortical gene expression after antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding

GPCRs in Oncology and Immunology

• Neutrophils are itching to specialize

• A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection

Industry News

• InterAx Biotech's AI platform unlocks new drug designs for diabetes, obesity, and cancer

• Crinetics Pharmaceuticals to Report Fourth Quarter and Full Year 2023 Financial Results on February 28, 2024

• Sosei Heptares Operational Highlights and Consolidated Results for 12 Months ended 31 December 2023

• Pioneering Research in GPCR Pharmacology: Unraveling the Secrets of Cellular Communication   

• Bowes Biomedical Investigator Takes Aim at Cracking Cellular Communication Code

• Aelis Farma will be at Bio Europe Spring in Barcelona 

GPCR Events, Meetings, and Webinars

• February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Research Fellow

• NEW  Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior 

• Director of Laboratory Operations - Single-molecule Imaging Center

• Scientific Assistant 

• Postdoctoral Fellowship- Mechanistic Biology 

• Research Scientist

• Post-Doc position

Join Dr. GPCR Ecosystem