📰 GPCR Weekly News, February 27 to March 5, 2023

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GPCR weekly newsletter is here! Prepare to stay informed of the most recent findings, developments, and news in the industry. Keep in mind that you can always change your email preferences in your account settings.

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Great News! We are excited to welcome you to the first Dr. GPCR Symposium event held on March 24th. If you'd like to present a poster, please submit yours today.

There is no limit to the number of posters we can accommodate, so hurry and submit your poster so that we can add it to the list of posters and increase the number of people who can ''stop by'' it on March 24th, 2023.

Below is your Classified GPCR News at a glance for February 27th to March 5th, 2023.

GPCRs in Cardiology, Endocrinology, and Taste

• Dietary compounds activate an insect gustatory receptor on enteroendocrine cells to elicit myosuppressin secretion.

GPCRs in Neuroscience

• Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain.

• Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs.

• Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

• Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein.

GPCRs in Oncology and Immunology

• GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis.

Methods & Updates in GPCR Research

• Time- and cost-efficient bacterial expression and purification of potato apyrase.

• FSHR activation through small molecule modulators: Mechanistic insights from MD simulations.

Reviews, GPCRs, and more

• Short-chain fatty acids: possible regulators of insulin secretion.

• Function and structure of bradykinin receptor 2 for drug discovery.

• Developing novel antifungals: lessons from G protein-coupled receptors.

• Function and regulation of GPR84 in human neutrophils.

Structural and Molecular Insights into GPCR Function

• The activation mechanism and antibody binding mode for orphan GPR20.

• Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells.

Industry News

• Design Pharmaceuticals has a new website

• Confo Therapeutics Announces Global Licensing Agreement with Lilly for Peripheral Pain Candidate, CFTX-1554

• Cardiff-based Antiverse raises €2.8M for its computational antibody drug discovery platform

• Antiverse identifies therapeutic antibodies targeting GPCRs

• CEO Andrew Hopkins on Exscientias AI-Driven Approach to Modern Drug Discovery

• Arcoscreen will present in the start-up village at Future Labs Live Basel

• Exscientia Announces Collaboration with Charité to Advance Development of Precision Medicine Platform

• Sosei Heptares and Neurocrine Biosciences won Top Out-Licensing Deal on the 8th annual Japan Deal of the Year

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline extended to March 31st, 2023.

GPCR Events, Meetings, and Webinars

• ERNEST ECI zoominar. (March 9)

• GEM2023. (March 14-17, 2023).

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• PhD candidate or Postdoc.

• Director, Head of PMO.

• Associate Scientist, Protein Science.

• PhD Studentship - Integrated Approaches In Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory Receptor Gpr84.

• PhD Studentship - Insight Into The Neuroprotective Function Of The Prostaglandin Receptor Ep2.

• Computational drug design PhD student at the Department of Drug Design and Pharmacology.

• Computational drug design postdoc at the Department of Drug Design and Pharmacology.

• Software / database development PhD student at Department of Drug Design and Pharmacology.

• Software / database development postdoc at the Department of Drug Design and Pharmacology.

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